Population Pharmacokinetic-Pharmacodynamic (popPK/PD) Relationship of Orismilast, A Potent and Selective PDE4B/D Inhibitor, in Atopic Dermatitis

Population Pharmacokinetic-Pharmacodynamic (popPK/PD) Relationship of Orismilast, A Potent and Selective PDE4B/D Inhibitor, in Atopic Dermatitis

Abstract Introduction Orismilast is a novel oral selective inhibitor of phosphodiesterase 4B and 4D subtypes (PDE4B/D) in clinical development for treatment of atopic dermatitis (AD) and other inflammatory skin conditions. Herein, we describe a pharmacokinetic/pharmacodynamic (PK/PD) analysis compar...

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Bibliographic Details
Main Authors: Richard B. Warren, Anne Weiss, Jakob Felding, Morten O. A. Sommer
Format: Article
Language:English
Published: Adis, Springer Healthcare 2025-03-01
Series:Dermatology and Therapy
Subjects:
Atopic dermatitis
Pharmacokinetics
Pharmacodynamics
Orismilast
PDE4
Online Access:https://doi.org/10.1007/s13555-025-01371-9
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