Ubiquitin-dependent translation control mechanisms: Degradation and beyond
Summary: Translation control mechanisms connect the largely static genome to the highly dynamic proteome. At each step in the translation cycle, multiple layers of regulation enable efficient protein biogenesis under optimal conditions and mediate responses to acute environmental challenges. Recent...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724014013 |
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| author | Pierce W. Ford Mythreyi Narasimhan Eric J. Bennett |
| author_facet | Pierce W. Ford Mythreyi Narasimhan Eric J. Bennett |
| author_sort | Pierce W. Ford |
| collection | DOAJ |
| description | Summary: Translation control mechanisms connect the largely static genome to the highly dynamic proteome. At each step in the translation cycle, multiple layers of regulation enable efficient protein biogenesis under optimal conditions and mediate responses to acute environmental challenges. Recent research has demonstrated that individual ribosomal protein ubiquitylation events act as molecular signals to specify quality control pathway outcomes. Here, we synthesize current knowledge of ubiquitin-mediated translation control mechanisms and highlight key outstanding questions. We compare and contrast ubiquitin-dependent mechanisms that regulate ribosome-associated quality control pathways at several steps in the translation cycle. We also explore how distinct ribosome ubiquitylation events on specific ribosomal proteins impact translation activity and how defects in specific ubiquitin-mediated regulatory steps impact physiology and health. |
| format | Article |
| id | doaj-art-d4145f1a3d174e0ab77e37c0dcbb6d54 |
| institution | DOAJ |
| issn | 2211-1247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-d4145f1a3d174e0ab77e37c0dcbb6d542025-08-20T02:49:59ZengElsevierCell Reports2211-12472024-12-01431211505010.1016/j.celrep.2024.115050Ubiquitin-dependent translation control mechanisms: Degradation and beyondPierce W. Ford0Mythreyi Narasimhan1Eric J. Bennett2School of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USASchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USASchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA; Corresponding authorSummary: Translation control mechanisms connect the largely static genome to the highly dynamic proteome. At each step in the translation cycle, multiple layers of regulation enable efficient protein biogenesis under optimal conditions and mediate responses to acute environmental challenges. Recent research has demonstrated that individual ribosomal protein ubiquitylation events act as molecular signals to specify quality control pathway outcomes. Here, we synthesize current knowledge of ubiquitin-mediated translation control mechanisms and highlight key outstanding questions. We compare and contrast ubiquitin-dependent mechanisms that regulate ribosome-associated quality control pathways at several steps in the translation cycle. We also explore how distinct ribosome ubiquitylation events on specific ribosomal proteins impact translation activity and how defects in specific ubiquitin-mediated regulatory steps impact physiology and health.http://www.sciencedirect.com/science/article/pii/S2211124724014013CP: Molecular biology |
| spellingShingle | Pierce W. Ford Mythreyi Narasimhan Eric J. Bennett Ubiquitin-dependent translation control mechanisms: Degradation and beyond Cell Reports CP: Molecular biology |
| title | Ubiquitin-dependent translation control mechanisms: Degradation and beyond |
| title_full | Ubiquitin-dependent translation control mechanisms: Degradation and beyond |
| title_fullStr | Ubiquitin-dependent translation control mechanisms: Degradation and beyond |
| title_full_unstemmed | Ubiquitin-dependent translation control mechanisms: Degradation and beyond |
| title_short | Ubiquitin-dependent translation control mechanisms: Degradation and beyond |
| title_sort | ubiquitin dependent translation control mechanisms degradation and beyond |
| topic | CP: Molecular biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724014013 |
| work_keys_str_mv | AT piercewford ubiquitindependenttranslationcontrolmechanismsdegradationandbeyond AT mythreyinarasimhan ubiquitindependenttranslationcontrolmechanismsdegradationandbeyond AT ericjbennett ubiquitindependenttranslationcontrolmechanismsdegradationandbeyond |