Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities
The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. This family significantly influences several essential cellul...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1569927/full |
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| author | Mingyang Feng Yong He Hui Wang |
| author_facet | Mingyang Feng Yong He Hui Wang |
| author_sort | Mingyang Feng |
| collection | DOAJ |
| description | The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. This family significantly influences several essential cellular processes, including cell adhesion, proliferation, migration, differentiation, and apoptosis. ANXAs are integral to physiological regulation and the pathological states associated with liver diseases. Dysregulated expression of ANXAs has been linked to a spectrum of liver conditions, including metabolic dysfunction, hepatocyte damage, fibrosis, and tumor formation. In this review, we outline recent advancements in understanding the roles of ANXAs in liver diseases. Further investigation into the roles of ANXAs in the liver could enhance our understanding of the mechanisms underlying liver diseases and may identify biomarkers and therapeutic targets for liver diseases in the future. |
| format | Article |
| id | doaj-art-d410e8cdc0a3408f8fa30e332c1ba3a0 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-d410e8cdc0a3408f8fa30e332c1ba3a02025-08-20T03:28:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15699271569927Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunitiesMingyang Feng0Yong He1Hui Wang2Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. This family significantly influences several essential cellular processes, including cell adhesion, proliferation, migration, differentiation, and apoptosis. ANXAs are integral to physiological regulation and the pathological states associated with liver diseases. Dysregulated expression of ANXAs has been linked to a spectrum of liver conditions, including metabolic dysfunction, hepatocyte damage, fibrosis, and tumor formation. In this review, we outline recent advancements in understanding the roles of ANXAs in liver diseases. Further investigation into the roles of ANXAs in the liver could enhance our understanding of the mechanisms underlying liver diseases and may identify biomarkers and therapeutic targets for liver diseases in the future.https://www.frontiersin.org/articles/10.3389/fphar.2025.1569927/fullannexinsANXA2liver diseaseMAFLDHCC |
| spellingShingle | Mingyang Feng Yong He Hui Wang Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities Frontiers in Pharmacology annexins ANXA2 liver disease MAFLD HCC |
| title | Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities |
| title_full | Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities |
| title_fullStr | Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities |
| title_full_unstemmed | Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities |
| title_short | Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities |
| title_sort | role of the annexin a protein family in liver diseases insights and therapeutic opportunities |
| topic | annexins ANXA2 liver disease MAFLD HCC |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1569927/full |
| work_keys_str_mv | AT mingyangfeng roleoftheannexinaproteinfamilyinliverdiseasesinsightsandtherapeuticopportunities AT yonghe roleoftheannexinaproteinfamilyinliverdiseasesinsightsandtherapeuticopportunities AT huiwang roleoftheannexinaproteinfamilyinliverdiseasesinsightsandtherapeuticopportunities |