Collagen synthesis in the skin: genetic and epigenetic aspects
One of the most important functions of the skin, mechanical, is provided by collagen fibers and their interaction with other elements of the extracellular matrix. Synthesis of collagen fibers is a complex multistep process. At each stage, disturbances may occur, leading, as a result, to a decrease i...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2022-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4923 |
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| author | N. N. Potekaev O. B. Borzykh N. A. Shnayder M. M. Petrova E. I. Karpova R. F. Nasyrova |
| author_facet | N. N. Potekaev O. B. Borzykh N. A. Shnayder M. M. Petrova E. I. Karpova R. F. Nasyrova |
| author_sort | N. N. Potekaev |
| collection | DOAJ |
| description | One of the most important functions of the skin, mechanical, is provided by collagen fibers and their interaction with other elements of the extracellular matrix. Synthesis of collagen fibers is a complex multistep process. At each stage, disturbances may occur, leading, as a result, to a decrease in the mechanical properties of the connective tissue. In clinical practice, disorders of collagen synthesis are manifested through increased skin laxity and looseness and premature aging. In addition to the clinical presentation, it is important for the cosmetologist and dermatologist to understand the etiology and pathogenesis of collagenopathies. The present review summarizes and systematizes available information about the role of genetic and epigenetic factors in the synthesis of collagen fibers in the skin. Understanding the etiology of collagen synthesis disorders can allow doctors to prescribe pathogenetically grounded treatment with the most effective results and minimize adverse reactions. |
| format | Article |
| id | doaj-art-d410cce84265411091b47517ffabb287 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-d410cce84265411091b47517ffabb2872025-08-20T04:00:10ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842022-10-0121321722610.20538/1682-0363-2022-3-217-2262933Collagen synthesis in the skin: genetic and epigenetic aspectsN. N. Potekaev0O. B. Borzykh1N. A. Shnayder2M. M. Petrova3E. I. Karpova4R. F. Nasyrova5Pirogov Russian National Research Medical University; Moscow Research and Practical Center for Dermatology and Cosmetology, Department of HealthcareV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityV.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Bekhterev Psychoneurological Research InstituteV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityPirogov Russian National Research Medical UniversityBekhterev Psychoneurological Research Institute; Kazan Federal UniversityOne of the most important functions of the skin, mechanical, is provided by collagen fibers and their interaction with other elements of the extracellular matrix. Synthesis of collagen fibers is a complex multistep process. At each stage, disturbances may occur, leading, as a result, to a decrease in the mechanical properties of the connective tissue. In clinical practice, disorders of collagen synthesis are manifested through increased skin laxity and looseness and premature aging. In addition to the clinical presentation, it is important for the cosmetologist and dermatologist to understand the etiology and pathogenesis of collagenopathies. The present review summarizes and systematizes available information about the role of genetic and epigenetic factors in the synthesis of collagen fibers in the skin. Understanding the etiology of collagen synthesis disorders can allow doctors to prescribe pathogenetically grounded treatment with the most effective results and minimize adverse reactions.https://bulletin.ssmu.ru/jour/article/view/4923skin collagencollagen synthesiscollagenopathygene polymorphism |
| spellingShingle | N. N. Potekaev O. B. Borzykh N. A. Shnayder M. M. Petrova E. I. Karpova R. F. Nasyrova Collagen synthesis in the skin: genetic and epigenetic aspects Бюллетень сибирской медицины skin collagen collagen synthesis collagenopathy gene polymorphism |
| title | Collagen synthesis in the skin: genetic and epigenetic aspects |
| title_full | Collagen synthesis in the skin: genetic and epigenetic aspects |
| title_fullStr | Collagen synthesis in the skin: genetic and epigenetic aspects |
| title_full_unstemmed | Collagen synthesis in the skin: genetic and epigenetic aspects |
| title_short | Collagen synthesis in the skin: genetic and epigenetic aspects |
| title_sort | collagen synthesis in the skin genetic and epigenetic aspects |
| topic | skin collagen collagen synthesis collagenopathy gene polymorphism |
| url | https://bulletin.ssmu.ru/jour/article/view/4923 |
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