MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis
Colorectal cancer (CRC) represents a highly common gastrointestinal malignancy ranking among the top three most frequently diagnosed cancers in the digestive system. The disease’s high mortality rate makes treatment particularly difficult. As a result, thorough research into the cause and effective...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1619526/full |
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| author | Haihong Lin Haihong Lin Jun Zhou Ying He Yifan Zhu Yifan Zhu Puwen Chen Hongwei Yan Junyun Huang Junyun Huang Junyun Huang Ersheng Gong Ersheng Gong Xiaoling Wang Xiaoling Wang Xiaoling Wang |
| author_facet | Haihong Lin Haihong Lin Jun Zhou Ying He Yifan Zhu Yifan Zhu Puwen Chen Hongwei Yan Junyun Huang Junyun Huang Junyun Huang Ersheng Gong Ersheng Gong Xiaoling Wang Xiaoling Wang Xiaoling Wang |
| author_sort | Haihong Lin |
| collection | DOAJ |
| description | Colorectal cancer (CRC) represents a highly common gastrointestinal malignancy ranking among the top three most frequently diagnosed cancers in the digestive system. The disease’s high mortality rate makes treatment particularly difficult. As a result, thorough research into the cause and effective treatment of CRC is especially crucial. The macrophage’s remarkable functional flexibility, as a cell with strong immunological effects, allows it to demonstrate both anti-tumor and tumor-inducing activities. MicroRNAs (miRNAs), functioning as short non-protein-coding RNAs, mediate post-transcriptional regulation through mRNA destabilization and translational suppression, and they play a unique function in macrophage formation, polarization processes, and anti-inflammatory activity. Elucidating the crosstalk between miRNA-mediated gene regulation and macrophage functional polarization in CRC pathogenesis constitutes a critical research priority. We first provide a brief overview of the epidemiological of CRC, systematically summarising the origin of macrophages, their physiological functions, and their potential pathogenic mechanisms in colorectal carcinogenesis. Subsequently, we elaborated in depth on the critical role of miRNAs in regulating macrophage polarisation status. Ultimately, this paper comprehensively explores the mechanistic involvement of miRNA-macrophage interactions in CRC progression. |
| format | Article |
| id | doaj-art-d40dc2a30da24d4283ea5ded21b22dc5 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-d40dc2a30da24d4283ea5ded21b22dc52025-08-20T02:50:29ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-07-011310.3389/fcell.2025.16195261619526MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesisHaihong Lin0Haihong Lin1Jun Zhou2Ying He3Yifan Zhu4Yifan Zhu5Puwen Chen6Hongwei Yan7Junyun Huang8Junyun Huang9Junyun Huang10Ersheng Gong11Ersheng Gong12Xiaoling Wang13Xiaoling Wang14Xiaoling Wang15Department of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, ChinaDepartment of Laboratory Medicine, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, ChinaDepartment of Laboratory Medicine, Shantou Yuehui Orthopedic Hospital, Shantou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou, ChinaSchool of Public Health and Health Management, Key Laboratory of Development and Utilization of Gannan Characteristic Food Function Component of Ganzhou, Gannan Medical University, Ganzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaCollege of Medical Technology, Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaColorectal cancer (CRC) represents a highly common gastrointestinal malignancy ranking among the top three most frequently diagnosed cancers in the digestive system. The disease’s high mortality rate makes treatment particularly difficult. As a result, thorough research into the cause and effective treatment of CRC is especially crucial. The macrophage’s remarkable functional flexibility, as a cell with strong immunological effects, allows it to demonstrate both anti-tumor and tumor-inducing activities. MicroRNAs (miRNAs), functioning as short non-protein-coding RNAs, mediate post-transcriptional regulation through mRNA destabilization and translational suppression, and they play a unique function in macrophage formation, polarization processes, and anti-inflammatory activity. Elucidating the crosstalk between miRNA-mediated gene regulation and macrophage functional polarization in CRC pathogenesis constitutes a critical research priority. We first provide a brief overview of the epidemiological of CRC, systematically summarising the origin of macrophages, their physiological functions, and their potential pathogenic mechanisms in colorectal carcinogenesis. Subsequently, we elaborated in depth on the critical role of miRNAs in regulating macrophage polarisation status. Ultimately, this paper comprehensively explores the mechanistic involvement of miRNA-macrophage interactions in CRC progression.https://www.frontiersin.org/articles/10.3389/fcell.2025.1619526/fullmicroRNAmacrophagescolorectal cancerextracellular vesiclescancer |
| spellingShingle | Haihong Lin Haihong Lin Jun Zhou Ying He Yifan Zhu Yifan Zhu Puwen Chen Hongwei Yan Junyun Huang Junyun Huang Junyun Huang Ersheng Gong Ersheng Gong Xiaoling Wang Xiaoling Wang Xiaoling Wang MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis Frontiers in Cell and Developmental Biology microRNA macrophages colorectal cancer extracellular vesicles cancer |
| title | MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis |
| title_full | MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis |
| title_fullStr | MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis |
| title_full_unstemmed | MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis |
| title_short | MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis |
| title_sort | microrna role in macrophage polarisation and colorectal cancer pathogenesis |
| topic | microRNA macrophages colorectal cancer extracellular vesicles cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1619526/full |
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