Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response
Abstract Background Clear cell renal cell carcinoma (ccRCC) commonly exhibits biallelic inactivation of VHL genes, profoundly impacting intracellular metabolic pathways and utilization of metabolic substrates. The aims of this study were to validate the metabolomic profile previously identified in c...
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| Main Authors: | Michinobu Ozawa, Sei Naito, Hideki Makinoshima, Hiromi Ito, Atsushi Tsuya, Takafumi Narisawa, Hiroki Fukuhara, Yuki Takai, Masaki Ushijima, Mayu Yagi, Hayato Nishida, Norihiko Tsuchiya |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-025-14661-4 |
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