Reversed halo sign: from a clinico-radiologic–pathologic point of view
Abstract Reversed halo sign (RHS) is characterized by a central ground-glass opacity surrounded by a crescentic or ring-shaped consolidation. It was originally described as a pathognomonic imaging feature of cryptogenic organizing pneumonia (COP), but has subsequently been observed in a wide variety...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02665-6 |
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| author | Yuan Ye Run Zhang Kaiyue Diao Hua Zhou Xuanli Xu Liangjie Fang Apoorva Sinha Lingfang Tu Jianya Zhou |
| author_facet | Yuan Ye Run Zhang Kaiyue Diao Hua Zhou Xuanli Xu Liangjie Fang Apoorva Sinha Lingfang Tu Jianya Zhou |
| author_sort | Yuan Ye |
| collection | DOAJ |
| description | Abstract Reversed halo sign (RHS) is characterized by a central ground-glass opacity surrounded by a crescentic or ring-shaped consolidation. It was originally described as a pathognomonic imaging feature of cryptogenic organizing pneumonia (COP), but has subsequently been observed in a wide variety of pulmonary disorders, including infectious and non-infectious diseases. Although RHS is currently considered as a non-specific and non-pathognomonic sign, a careful analysis of its radiologic characteristics together with clinical features can greatly facilitate the differential diagnosis. The paper presents a state-of-the-art review of RHS, we retrospectively review the definition of RHS in chronological order and comprehensively summarize the spectrum of pulmonary diseases associated with RHS. In addition, the radiologic–pathologic correlations of RHS in different disease entities are systemically discussed and an integrated approach is proposed to establish the differential diagnosis of RHS. |
| format | Article |
| id | doaj-art-d405c8408f55482f85cbcd02c5bb0fd5 |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-d405c8408f55482f85cbcd02c5bb0fd52025-08-20T02:10:35ZengBMCEuropean Journal of Medical Research2047-783X2025-06-0130111310.1186/s40001-025-02665-6Reversed halo sign: from a clinico-radiologic–pathologic point of viewYuan Ye0Run Zhang1Kaiyue Diao2Hua Zhou3Xuanli Xu4Liangjie Fang5Apoorva Sinha6Lingfang Tu7Jianya Zhou8Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineEmergency and Intensive Care Unit Center, Department of Intensive Care Unit, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineFaculty of Clinical Medicine, Zhejiang University School of MedicineDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract Reversed halo sign (RHS) is characterized by a central ground-glass opacity surrounded by a crescentic or ring-shaped consolidation. It was originally described as a pathognomonic imaging feature of cryptogenic organizing pneumonia (COP), but has subsequently been observed in a wide variety of pulmonary disorders, including infectious and non-infectious diseases. Although RHS is currently considered as a non-specific and non-pathognomonic sign, a careful analysis of its radiologic characteristics together with clinical features can greatly facilitate the differential diagnosis. The paper presents a state-of-the-art review of RHS, we retrospectively review the definition of RHS in chronological order and comprehensively summarize the spectrum of pulmonary diseases associated with RHS. In addition, the radiologic–pathologic correlations of RHS in different disease entities are systemically discussed and an integrated approach is proposed to establish the differential diagnosis of RHS.https://doi.org/10.1186/s40001-025-02665-6Computed tomographyReversed halo signGround-glass opacityConsolidation |
| spellingShingle | Yuan Ye Run Zhang Kaiyue Diao Hua Zhou Xuanli Xu Liangjie Fang Apoorva Sinha Lingfang Tu Jianya Zhou Reversed halo sign: from a clinico-radiologic–pathologic point of view European Journal of Medical Research Computed tomography Reversed halo sign Ground-glass opacity Consolidation |
| title | Reversed halo sign: from a clinico-radiologic–pathologic point of view |
| title_full | Reversed halo sign: from a clinico-radiologic–pathologic point of view |
| title_fullStr | Reversed halo sign: from a clinico-radiologic–pathologic point of view |
| title_full_unstemmed | Reversed halo sign: from a clinico-radiologic–pathologic point of view |
| title_short | Reversed halo sign: from a clinico-radiologic–pathologic point of view |
| title_sort | reversed halo sign from a clinico radiologic pathologic point of view |
| topic | Computed tomography Reversed halo sign Ground-glass opacity Consolidation |
| url | https://doi.org/10.1186/s40001-025-02665-6 |
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