Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study
Individuals with schizophrenia (SZ) exhibit deficits in speech perception in noise, which are closely related to their abnormalities in auditory working memory (WM). Auditory WM, especially the non-verbal auditory WM, serves as a bridge between perception, action, and long-term memory, playing a cru...
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| Language: | English |
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Elsevier
2025-09-01
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| Series: | Schizophrenia Research: Cognition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215001325000204 |
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| author | Lei Liu Wenyang Han Juntao Yu Lingna Lou Dewen Zhou Liang Li Peng Xu Feng Zou |
| author_facet | Lei Liu Wenyang Han Juntao Yu Lingna Lou Dewen Zhou Liang Li Peng Xu Feng Zou |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | Individuals with schizophrenia (SZ) exhibit deficits in speech perception in noise, which are closely related to their abnormalities in auditory working memory (WM). Auditory WM, especially the non-verbal auditory WM, serves as a bridge between perception, action, and long-term memory, playing a crucial role in integrating sound sequences to facilitate auditory object perception and auditory scene analysis (ASA). Although considerable research has been conducted on auditory sensory memory and visual WM in schizophrenia, studies specifically addressing non-verbal auditory WM remain scarce. Therefore, this study recorded the behavioral performance and event related potentials of 36 SZ and 36 healthy controls (HC) during a modified non-musical tone-sequence delayed matching-to-sample task (DMTS). The results showed that, in the tone-sequence DMTS, SZ had not only lower accuracy but also slower reaction times compared to the HC. More importantly, during the retention period, the memory maintenance of SZ begins to decay rapidly from the mid-stage, manifested by a significantly reduction in the late sustained anterior negativity (SAN2). Meanwhile, the early sustained anterior negativity (SAN1) in patients showed a significant correlation with their general pathological symptoms. The pathological symptoms can be predicted by the SAN1 under load 4 condition. This study provides empirical evidence for the impairment of non-verbal auditory WM maintenance in schizophrenia, which is of significant importance for understanding the auditory dysfunction and ASA difficulties experienced by SZ. |
| format | Article |
| id | doaj-art-d405bc6707a14e3fa8635d7fde0101bf |
| institution | OA Journals |
| issn | 2215-0013 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Schizophrenia Research: Cognition |
| spelling | doaj-art-d405bc6707a14e3fa8635d7fde0101bf2025-08-20T02:31:43ZengElsevierSchizophrenia Research: Cognition2215-00132025-09-014110036210.1016/j.scog.2025.100362Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP studyLei Liu0Wenyang Han1Juntao Yu2Lingna Lou3Dewen Zhou4Liang Li5Peng Xu6Feng Zou7School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, ChinaDepartment of Psychiatry, The 967th Hospital of PLA Joint Logistics Support Force, Dalian, ChinaDepartment of Psychiatry, The 967th Hospital of PLA Joint Logistics Support Force, Dalian, ChinaFaculty of Philosophy, Martin Luther University Halle-Wittenberg, Halle (Saale), Sachsen-Anhalt, GermanyInstitute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaSchool of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, ChinaDepartment of Psychiatry, The 967th Hospital of PLA Joint Logistics Support Force, Dalian, China; Corresponding authors at: Department of Psychiatry, The 967th Hospital of PLA Joint Logistics Support Force, Dalian 116000, China.Department of Psychiatry, The 967th Hospital of PLA Joint Logistics Support Force, Dalian, China; Corresponding authors at: Department of Psychiatry, The 967th Hospital of PLA Joint Logistics Support Force, Dalian 116000, China.Individuals with schizophrenia (SZ) exhibit deficits in speech perception in noise, which are closely related to their abnormalities in auditory working memory (WM). Auditory WM, especially the non-verbal auditory WM, serves as a bridge between perception, action, and long-term memory, playing a crucial role in integrating sound sequences to facilitate auditory object perception and auditory scene analysis (ASA). Although considerable research has been conducted on auditory sensory memory and visual WM in schizophrenia, studies specifically addressing non-verbal auditory WM remain scarce. Therefore, this study recorded the behavioral performance and event related potentials of 36 SZ and 36 healthy controls (HC) during a modified non-musical tone-sequence delayed matching-to-sample task (DMTS). The results showed that, in the tone-sequence DMTS, SZ had not only lower accuracy but also slower reaction times compared to the HC. More importantly, during the retention period, the memory maintenance of SZ begins to decay rapidly from the mid-stage, manifested by a significantly reduction in the late sustained anterior negativity (SAN2). Meanwhile, the early sustained anterior negativity (SAN1) in patients showed a significant correlation with their general pathological symptoms. The pathological symptoms can be predicted by the SAN1 under load 4 condition. This study provides empirical evidence for the impairment of non-verbal auditory WM maintenance in schizophrenia, which is of significant importance for understanding the auditory dysfunction and ASA difficulties experienced by SZ.http://www.sciencedirect.com/science/article/pii/S2215001325000204SchizophreniaAuditory working memoryNon-verbal auditory WMERPSustained anterior negativity |
| spellingShingle | Lei Liu Wenyang Han Juntao Yu Lingna Lou Dewen Zhou Liang Li Peng Xu Feng Zou Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study Schizophrenia Research: Cognition Schizophrenia Auditory working memory Non-verbal auditory WM ERP Sustained anterior negativity |
| title | Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study |
| title_full | Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study |
| title_fullStr | Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study |
| title_full_unstemmed | Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study |
| title_short | Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study |
| title_sort | impaired non verbal auditory memory maintenance in schizophrenia an erp study |
| topic | Schizophrenia Auditory working memory Non-verbal auditory WM ERP Sustained anterior negativity |
| url | http://www.sciencedirect.com/science/article/pii/S2215001325000204 |
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