Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens
Clostridium perfringens causes pyogenic liver abscesses, which are rare but rapidly fatal infections. These abscesses often occur in patients with immunodeficiency due to malignancy, liver cirrhosis, diabetes mellitus, or organ transplantation. The identification of gram-positive bacilli in septice...
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The Journal of Infection in Developing Countries
2022-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/13756 |
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| author | Jiang Guo Changqing Li Xuesong Gao |
| author_facet | Jiang Guo Changqing Li Xuesong Gao |
| author_sort | Jiang Guo |
| collection | DOAJ |
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Clostridium perfringens causes pyogenic liver abscesses, which are rare but rapidly fatal infections. These abscesses often occur in patients with immunodeficiency due to malignancy, liver cirrhosis, diabetes mellitus, or organ transplantation. The identification of gram-positive bacilli in septicemia, the presence of gas-forming liver damage and intravascular hemolysis are manifestations of Clostridium perfringens infection. Clostridioides toxin A hydrolyzes phospholipids in erythrocyte membranes, causing spherocytosis and subsequent intravascular hemolysis, resulting in rapid deterioration and a high mortality rate. A 62-year-old man with recurrent hepatocellular carcinoma complained of a high fever and abdominal pain one day after microwave ablation. Abdominal computed tomography revealed gas-containing lesions in the liver. His condition was complicated with massive hemolysis. Laboratory examinations revealed low hemoglobin, high serum lactate dehydrogenase, and elevated indirect bilirubin levels, suggesting massive intravascular hemolysis. Although aggressive treatment was applied, he died within 16 hours after onset of the infection. After the patient died, a blood culture indicated Clostridium perfringens positivity. Clostridium perfringens-induced septicemia with massive hemolysis is rare but rapidly leads to a severe prognosis. It is important to identify Clostridium perfringens infection early and initiate effective treatment, especially abscess aspiration, which should be performed as soon as possible.
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| format | Article |
| id | doaj-art-d4044dc5eff546e586656f91d70921d5 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-d4044dc5eff546e586656f91d70921d52025-08-20T02:57:01ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-01-01160110.3855/jidc.13756Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringensJiang Guo0Changqing Li1Xuesong Gao2Department of Interventional Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Interventional Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China Clostridium perfringens causes pyogenic liver abscesses, which are rare but rapidly fatal infections. These abscesses often occur in patients with immunodeficiency due to malignancy, liver cirrhosis, diabetes mellitus, or organ transplantation. The identification of gram-positive bacilli in septicemia, the presence of gas-forming liver damage and intravascular hemolysis are manifestations of Clostridium perfringens infection. Clostridioides toxin A hydrolyzes phospholipids in erythrocyte membranes, causing spherocytosis and subsequent intravascular hemolysis, resulting in rapid deterioration and a high mortality rate. A 62-year-old man with recurrent hepatocellular carcinoma complained of a high fever and abdominal pain one day after microwave ablation. Abdominal computed tomography revealed gas-containing lesions in the liver. His condition was complicated with massive hemolysis. Laboratory examinations revealed low hemoglobin, high serum lactate dehydrogenase, and elevated indirect bilirubin levels, suggesting massive intravascular hemolysis. Although aggressive treatment was applied, he died within 16 hours after onset of the infection. After the patient died, a blood culture indicated Clostridium perfringens positivity. Clostridium perfringens-induced septicemia with massive hemolysis is rare but rapidly leads to a severe prognosis. It is important to identify Clostridium perfringens infection early and initiate effective treatment, especially abscess aspiration, which should be performed as soon as possible. https://jidc.org/index.php/journal/article/view/13756Liver infectionClostridium perfringenshemolysishepatocellular carcinomamicrowave ablation |
| spellingShingle | Jiang Guo Changqing Li Xuesong Gao Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens Journal of Infection in Developing Countries Liver infection Clostridium perfringens hemolysis hepatocellular carcinoma microwave ablation |
| title | Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens |
| title_full | Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens |
| title_fullStr | Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens |
| title_full_unstemmed | Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens |
| title_short | Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens |
| title_sort | liver abscess after microwave ablation of hepatocellular carcinoma caused by clostridium perfringens |
| topic | Liver infection Clostridium perfringens hemolysis hepatocellular carcinoma microwave ablation |
| url | https://jidc.org/index.php/journal/article/view/13756 |
| work_keys_str_mv | AT jiangguo liverabscessaftermicrowaveablationofhepatocellularcarcinomacausedbyclostridiumperfringens AT changqingli liverabscessaftermicrowaveablationofhepatocellularcarcinomacausedbyclostridiumperfringens AT xuesonggao liverabscessaftermicrowaveablationofhepatocellularcarcinomacausedbyclostridiumperfringens |