Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn
Anti-D antibody is the most common cause of hemolytic disease of the newborn (HDN). Other antigens have emerged, causing significant damage to the newborn. We report a case of a 31-week dichorionic diamniotic twin born emergently to a mother with anti-C and anti-D antibodies who required multiple pe...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2024/9180404 |
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| author | Matthew Reinhardt Marya L. Strand Dajana Sabic |
| author_facet | Matthew Reinhardt Marya L. Strand Dajana Sabic |
| author_sort | Matthew Reinhardt |
| collection | DOAJ |
| description | Anti-D antibody is the most common cause of hemolytic disease of the newborn (HDN). Other antigens have emerged, causing significant damage to the newborn. We report a case of a 31-week dichorionic diamniotic twin born emergently to a mother with anti-C and anti-D antibodies who required multiple percutaneous umbilical cord blood sampling (PUBS) and transfusions. Extensive resuscitation at birth was required due to severe anemia, hypovolemia, and prematurity. Ensuing liver damage occurred with subsequent profound coagulopathy, transaminitis, and direct hyperbilirubinemia that required significant support. This patient developed several unique findings including the inability to monitor oxygen saturations due to dermal bilirubin deposits and staining of baby teeth. This case report highlights the importance of early identification of additional Rh antibodies due to concern for development of more severe forms of HDN. |
| format | Article |
| id | doaj-art-d4030a6fb70e4d10ab083583ecb5202f |
| institution | DOAJ |
| issn | 2090-6811 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-d4030a6fb70e4d10ab083583ecb5202f2025-08-20T03:23:47ZengWileyCase Reports in Pediatrics2090-68112024-01-01202410.1155/2024/9180404Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the NewbornMatthew Reinhardt0Marya L. Strand1Dajana Sabic2Department of PediatricsDepartment of Neonatal-Perinatal MedicineDepartment of PediatricsAnti-D antibody is the most common cause of hemolytic disease of the newborn (HDN). Other antigens have emerged, causing significant damage to the newborn. We report a case of a 31-week dichorionic diamniotic twin born emergently to a mother with anti-C and anti-D antibodies who required multiple percutaneous umbilical cord blood sampling (PUBS) and transfusions. Extensive resuscitation at birth was required due to severe anemia, hypovolemia, and prematurity. Ensuing liver damage occurred with subsequent profound coagulopathy, transaminitis, and direct hyperbilirubinemia that required significant support. This patient developed several unique findings including the inability to monitor oxygen saturations due to dermal bilirubin deposits and staining of baby teeth. This case report highlights the importance of early identification of additional Rh antibodies due to concern for development of more severe forms of HDN.http://dx.doi.org/10.1155/2024/9180404 |
| spellingShingle | Matthew Reinhardt Marya L. Strand Dajana Sabic Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn Case Reports in Pediatrics |
| title | Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn |
| title_full | Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn |
| title_fullStr | Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn |
| title_full_unstemmed | Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn |
| title_short | Hepatic Failure and Hyperbilirubinemia Secondary to Hemolytic Disease of the Newborn |
| title_sort | hepatic failure and hyperbilirubinemia secondary to hemolytic disease of the newborn |
| url | http://dx.doi.org/10.1155/2024/9180404 |
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