IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection

IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection

IntroductionMalaria remains a significant public health challenge in Brazil, where Plasmodium vivax (P. vivax) is the predominant species. Dysregulated immune responses contribute substantially to malaria pathogenesis. Indoleamine 2,3-dioxygenase (IDO) mediates the catabolism of tryptophan (TRP) int...

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Main Authors: Rafaella Oliveira dos Santos, Nani Oliveira Carvalho, Thiago Barros do Nascimento de Morais, Wlademir Braga Salgado Sobrinho, Maria Geuziane Soares da Cruz, Elaine Speziali de Faria, Fernanda Fortes de Araújo, Vanessa Peruhype Magalhães, Stefanie Costa Pinto Lopes, Adriana Malheiros, Adolfo José da Mota, Helton da Costa Santiago, Paulo Afonso Nogueira, Andréa Teixeira de Carvalho, Marcus Vinícius Guimarães de Lacerda, Pritesh Lalwani
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Plasmodium vivax
malaria
indoleamine 2,3-dioxygenase
tryptophan catabolism
kynurenine
regulatory T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1474447/full
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