CLIPPERS. Three clinical cases and review

CLIPPERS (Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a rare inflammatory disease of the central nervous system, during which the pons of the brain is damaged. This disease was described for the first time in 2010 by S.J. Pittock et.al. At presen...

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Main Authors: L. N. Prakhova, A. S. Parfyonova, Zh. I. Savintseva, A. G. Ilves, E. V. Bubnova, V. S. Krasnov, A. M. Tarasova, N. A. Totolyan
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2020-01-01
Series:Бюллетень сибирской медицины
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Online Access:https://bulletin.ssmu.ru/jour/article/view/2579
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author L. N. Prakhova
A. S. Parfyonova
Zh. I. Savintseva
A. G. Ilves
E. V. Bubnova
V. S. Krasnov
A. M. Tarasova
N. A. Totolyan
author_facet L. N. Prakhova
A. S. Parfyonova
Zh. I. Savintseva
A. G. Ilves
E. V. Bubnova
V. S. Krasnov
A. M. Tarasova
N. A. Totolyan
author_sort L. N. Prakhova
collection DOAJ
description CLIPPERS (Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a rare inflammatory disease of the central nervous system, during which the pons of the brain is damaged. This disease was described for the first time in 2010 by S.J. Pittock et.al. At present, there have been around 50 described cases of the disease. Up to the present moment, there are difficulties diagnosing this disease. In the article, a literature review and three clinical cases are presented. Furthermore, the necessity of further research is shown for improving the accuracy and specificity of the diagnostic criteria, as well as for defining biomarkers and developing algorithms of effective therapy.
format Article
id doaj-art-d40263f1c8fb45a998cd24758fccc751
institution Kabale University
issn 1682-0363
1819-3684
language English
publishDate 2020-01-01
publisher Siberian State Medical University (Tomsk)
record_format Article
series Бюллетень сибирской медицины
spelling doaj-art-d40263f1c8fb45a998cd24758fccc7512025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-01-0118425626510.20538/1682-0363-2019-4-256-2651587CLIPPERS. Three clinical cases and reviewL. N. Prakhova0A. S. Parfyonova1Zh. I. Savintseva2A. G. Ilves3E. V. Bubnova4V. S. Krasnov5A. M. Tarasova6N. A. Totolyan7N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)Academician I.P. Pavlov First St. Petersburg State Medical UniversityAcademician I.P. Pavlov First St. Petersburg State Medical UniversityAcademician I.P. Pavlov First St. Petersburg State Medical UniversityAcademician I.P. Pavlov First St. Petersburg State Medical UniversityCLIPPERS (Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a rare inflammatory disease of the central nervous system, during which the pons of the brain is damaged. This disease was described for the first time in 2010 by S.J. Pittock et.al. At present, there have been around 50 described cases of the disease. Up to the present moment, there are difficulties diagnosing this disease. In the article, a literature review and three clinical cases are presented. Furthermore, the necessity of further research is shown for improving the accuracy and specificity of the diagnostic criteria, as well as for defining biomarkers and developing algorithms of effective therapy.https://bulletin.ssmu.ru/jour/article/view/2579clippersmriglucocorticosteroids
spellingShingle L. N. Prakhova
A. S. Parfyonova
Zh. I. Savintseva
A. G. Ilves
E. V. Bubnova
V. S. Krasnov
A. M. Tarasova
N. A. Totolyan
CLIPPERS. Three clinical cases and review
Бюллетень сибирской медицины
clippers
mri
glucocorticosteroids
title CLIPPERS. Three clinical cases and review
title_full CLIPPERS. Three clinical cases and review
title_fullStr CLIPPERS. Three clinical cases and review
title_full_unstemmed CLIPPERS. Three clinical cases and review
title_short CLIPPERS. Three clinical cases and review
title_sort clippers three clinical cases and review
topic clippers
mri
glucocorticosteroids
url https://bulletin.ssmu.ru/jour/article/view/2579
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AT asparfyonova clippersthreeclinicalcasesandreview
AT zhisavintseva clippersthreeclinicalcasesandreview
AT agilves clippersthreeclinicalcasesandreview
AT evbubnova clippersthreeclinicalcasesandreview
AT vskrasnov clippersthreeclinicalcasesandreview
AT amtarasova clippersthreeclinicalcasesandreview
AT natotolyan clippersthreeclinicalcasesandreview