MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies

Abstract Transcriptome-wide association study (TWAS) has emerged as a powerful tool for translating the myriad variations identified by genome-wide association studies (GWAS) into regulated genes in the post-GWAS era. While integrating annotation information has been shown to enhance power, current...

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Bibliographic Details
Main Authors: Han Wang, Xiang Li, Teng Li, Zhe Li, Pak Chung Sham, Yan Dora Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Genome Biology
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Online Access:https://doi.org/10.1186/s13059-025-03485-x
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