Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years
Retroperitoneal liposarcoma (RPLS) is a rare and challenging soft tissue sarcoma, comprising 15–20% of adult retroperitoneal tumors. Despite surgical resection, recurrence rates are high, and adjuvant therapies are limited. We present a unique case of a 42-year-old woman with recurrent RPLS, who exp...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
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| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_77_25 |
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| author | Samir Gupta NH Mallikarjun Kaivalya R. Saoji Akshi Raj Tejus V. Nagireddy |
| author_facet | Samir Gupta NH Mallikarjun Kaivalya R. Saoji Akshi Raj Tejus V. Nagireddy |
| author_sort | Samir Gupta |
| collection | DOAJ |
| description | Retroperitoneal liposarcoma (RPLS) is a rare and challenging soft tissue sarcoma, comprising 15–20% of adult retroperitoneal tumors. Despite surgical resection, recurrence rates are high, and adjuvant therapies are limited. We present a unique case of a 42-year-old woman with recurrent RPLS, who experienced five recurrences and underwent four major surgeries over eight years. The most recent surgery involved removing a massive 13 kg, 40 × 25 × 17 cm tumor compressing adjacent organs. Histopathology consistently confirmed well-differentiated liposarcoma (WDLS), with one recurrence showing myxoid features. This case emphasizes the importance of aggressive surgical resection in managing recurrent RPLS, as well as vigilant long-term follow-up for early detection of recurrences. Despite significant morbidity from repeated surgeries, the patient showed remarkable recovery and long-term survival, highlighting the potential for favorable outcomes with individualized, multidisciplinary care. Our case, featuring long survival and multiple relapses, is unique, as only six cases with survival beyond six years have been reported in the past 12 years. |
| format | Article |
| id | doaj-art-d3fef0b6c61e438baffb9581df4d234a |
| institution | Kabale University |
| issn | 2589-8302 2589-8310 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj-art-d3fef0b6c61e438baffb9581df4d234a2025-08-20T03:37:31ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102025-07-0118470871110.4103/mjdrdypu.mjdrdypu_77_25Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight YearsSamir GuptaNH MallikarjunKaivalya R. SaojiAkshi RajTejus V. NagireddyRetroperitoneal liposarcoma (RPLS) is a rare and challenging soft tissue sarcoma, comprising 15–20% of adult retroperitoneal tumors. Despite surgical resection, recurrence rates are high, and adjuvant therapies are limited. We present a unique case of a 42-year-old woman with recurrent RPLS, who experienced five recurrences and underwent four major surgeries over eight years. The most recent surgery involved removing a massive 13 kg, 40 × 25 × 17 cm tumor compressing adjacent organs. Histopathology consistently confirmed well-differentiated liposarcoma (WDLS), with one recurrence showing myxoid features. This case emphasizes the importance of aggressive surgical resection in managing recurrent RPLS, as well as vigilant long-term follow-up for early detection of recurrences. Despite significant morbidity from repeated surgeries, the patient showed remarkable recovery and long-term survival, highlighting the potential for favorable outcomes with individualized, multidisciplinary care. Our case, featuring long survival and multiple relapses, is unique, as only six cases with survival beyond six years have been reported in the past 12 years.https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_77_25giant retroperitoneal sarcomamultiple relapsesrecurrent retroperitoneal liposarcoma |
| spellingShingle | Samir Gupta NH Mallikarjun Kaivalya R. Saoji Akshi Raj Tejus V. Nagireddy Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years Medical Journal of Dr. D.Y. Patil Vidyapeeth giant retroperitoneal sarcoma multiple relapses recurrent retroperitoneal liposarcoma |
| title | Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years |
| title_full | Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years |
| title_fullStr | Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years |
| title_full_unstemmed | Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years |
| title_short | Defying the Odds: A Rare Case of Giant Recurrent Retroperitoneal Liposarcoma Managed Over Eight Years |
| title_sort | defying the odds a rare case of giant recurrent retroperitoneal liposarcoma managed over eight years |
| topic | giant retroperitoneal sarcoma multiple relapses recurrent retroperitoneal liposarcoma |
| url | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_77_25 |
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