Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study
<b>Objective:</b> Our objective was to investigate the short-term effects of ambient ozone (O<sub>3</sub>) meteorological factors and their interactions on hospitalizations for cerebral infarction in Zhengzhou, China. <b>Methods</b>: Daily data on air pollutants,...
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MDPI AG
2025-07-01
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| Online Access: | https://www.mdpi.com/2305-6304/13/7/598 |
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| author | Yanzhe Chen Songtai Yang Hanya Que Jiamin Liu Zhe Wang Na Wang Yunkun Qin Meng Li Fang Zhou |
| author_facet | Yanzhe Chen Songtai Yang Hanya Que Jiamin Liu Zhe Wang Na Wang Yunkun Qin Meng Li Fang Zhou |
| author_sort | Yanzhe Chen |
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| description | <b>Objective:</b> Our objective was to investigate the short-term effects of ambient ozone (O<sub>3</sub>) meteorological factors and their interactions on hospitalizations for cerebral infarction in Zhengzhou, China. <b>Methods</b>: Daily data on air pollutants, meteorological factors, and hospitalization of cerebral infarction patients were collected from 1 January 2019 to 31 December 2023 in Zhengzhou, China. A generalized additive model was constructed to evaluate the association between ambient O<sub>3</sub> levels and hospitalization for cerebral infarction. A distributed lag non-linear model was applied to capture lagged and non-linear exposure effects. We further examined the modifying roles of temperature, humidity, wind speed, and atmospheric pressure, and conducted stratified analyses by sex, age, and season. <b>Results</b>: O<sub>3</sub> exposure was significantly associated with increased cerebral infarction risk, particularly during the warm season. A bimodal temperature-lag pattern was observed, as follows: moderate temperatures (10–20 °C) were associated with immediate effects, while cold (<10 °C) and hot (>30 °C) temperatures were linked to delayed risks. The association of O<sub>3</sub> and hospitalizations for cerebral infarction appeared stronger under high humidity, low wind speed, and low atmospheric pressure. <b>Conclusions</b>: Short-term O<sub>3</sub> exposure and adverse meteorological conditions are jointly associated with an elevated risk of cerebral infarction. Integrated air quality and weather-based warning systems are essential for targeted stroke prevention. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
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| series | Toxics |
| spelling | doaj-art-d3fc8d924a4b4cc3bff28aaa54162dae2025-08-20T03:56:46ZengMDPI AGToxics2305-63042025-07-0113759810.3390/toxics13070598Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series StudyYanzhe Chen0Songtai Yang1Hanya Que2Jiamin Liu3Zhe Wang4Na Wang5Yunkun Qin6Meng Li7Fang Zhou8Institute of Public Health Surveillance and Evaluation, Zhengzhou Center for Disease Control and Prevention, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaInstitute of Public Health Surveillance and Evaluation, Zhengzhou Center for Disease Control and Prevention, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China<b>Objective:</b> Our objective was to investigate the short-term effects of ambient ozone (O<sub>3</sub>) meteorological factors and their interactions on hospitalizations for cerebral infarction in Zhengzhou, China. <b>Methods</b>: Daily data on air pollutants, meteorological factors, and hospitalization of cerebral infarction patients were collected from 1 January 2019 to 31 December 2023 in Zhengzhou, China. A generalized additive model was constructed to evaluate the association between ambient O<sub>3</sub> levels and hospitalization for cerebral infarction. A distributed lag non-linear model was applied to capture lagged and non-linear exposure effects. We further examined the modifying roles of temperature, humidity, wind speed, and atmospheric pressure, and conducted stratified analyses by sex, age, and season. <b>Results</b>: O<sub>3</sub> exposure was significantly associated with increased cerebral infarction risk, particularly during the warm season. A bimodal temperature-lag pattern was observed, as follows: moderate temperatures (10–20 °C) were associated with immediate effects, while cold (<10 °C) and hot (>30 °C) temperatures were linked to delayed risks. The association of O<sub>3</sub> and hospitalizations for cerebral infarction appeared stronger under high humidity, low wind speed, and low atmospheric pressure. <b>Conclusions</b>: Short-term O<sub>3</sub> exposure and adverse meteorological conditions are jointly associated with an elevated risk of cerebral infarction. Integrated air quality and weather-based warning systems are essential for targeted stroke prevention.https://www.mdpi.com/2305-6304/13/7/598ozonecerebral infarctiontime-series studyinteractionmeteorological factors |
| spellingShingle | Yanzhe Chen Songtai Yang Hanya Que Jiamin Liu Zhe Wang Na Wang Yunkun Qin Meng Li Fang Zhou Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study Toxics ozone cerebral infarction time-series study interaction meteorological factors |
| title | Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study |
| title_full | Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study |
| title_fullStr | Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study |
| title_full_unstemmed | Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study |
| title_short | Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study |
| title_sort | interactive effects of ambient ozone and meteorological factors on cerebral infarction a five year time series study |
| topic | ozone cerebral infarction time-series study interaction meteorological factors |
| url | https://www.mdpi.com/2305-6304/13/7/598 |
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