CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway

CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway

IntroductionPemetrexed is a first line drug for brain metastases from lung cancer, either as monotherapy or combined with other drugs. The frequent occurrence of initial and acquired resistance to pemetrexed results in limited treatment effectiveness in brain metastases. CD146 was recently found to...

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Bibliographic Details
Main Authors: Hao Qu, Yan Fang, Feng Zhang, Wenwen Liu, Shengkai Xia, Wenzhe Duan, Kun Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
CD146
brain metastasis
chemotherapeutic resistance
pemetrexed
lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1502165/full
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