Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis
Lungs have long been considered sterile, but recent research has shown that a large number of microbiological organisms exist in the lungs of healthy subjects (including bacteria, fungi, and viruses), collectively known as the microbiome. It undergoes changes in patients with respiratory pathology....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1240&context=jmms |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850173860542939136 |
|---|---|
| author | Victoria Maria Ruta Teodora Gabriela Alexescu Ana Rodica Ungur Milena Adina Man Victoria Georgiana Sfirlea Iulia Olimpia Pfingstgraf Nicoleta Motoc Carmen Monica Pop |
| author_facet | Victoria Maria Ruta Teodora Gabriela Alexescu Ana Rodica Ungur Milena Adina Man Victoria Georgiana Sfirlea Iulia Olimpia Pfingstgraf Nicoleta Motoc Carmen Monica Pop |
| author_sort | Victoria Maria Ruta |
| collection | DOAJ |
| description | Lungs have long been considered sterile, but recent research has shown that a large number of microbiological organisms exist in the lungs of healthy subjects (including bacteria, fungi, and viruses), collectively known as the microbiome. It undergoes changes in patients with respiratory pathology. Studies in idiopathic pulmonary fibrosis show that a large number of bacteria or the abundant presence of potentially pathogenic bacteria can cause disease progression and exacerbation, and can implicitly increase mortality. There seems to be a quantitative balance, a well-established proportion between the components of this microbiome, which is disturbed during a disease and can reach a "state of pulmonary dysbiosis". Evidence suggests that the microbiome may be used as a prognostic biomarker and may also explain the pathogenesis of interstitial fibrosis. |
| format | Article |
| id | doaj-art-d3f776f85fd24483bdb08030d72eef44 |
| institution | OA Journals |
| issn | 2392-7674 2392-7674 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-d3f776f85fd24483bdb08030d72eef442025-08-20T02:19:46ZengMDPI AGJournal of Mind and Medical Sciences2392-76742392-76742020-10-017216216710.22543/7674.72.P162167Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosisVictoria Maria Ruta0Teodora Gabriela AlexescuAna Rodica UngurMilena Adina ManVictoria Georgiana SfirleaIulia Olimpia PfingstgrafNicoleta MotocCarmen Monica PopIULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, CLUJ NAPOCA, ROMANIALungs have long been considered sterile, but recent research has shown that a large number of microbiological organisms exist in the lungs of healthy subjects (including bacteria, fungi, and viruses), collectively known as the microbiome. It undergoes changes in patients with respiratory pathology. Studies in idiopathic pulmonary fibrosis show that a large number of bacteria or the abundant presence of potentially pathogenic bacteria can cause disease progression and exacerbation, and can implicitly increase mortality. There seems to be a quantitative balance, a well-established proportion between the components of this microbiome, which is disturbed during a disease and can reach a "state of pulmonary dysbiosis". Evidence suggests that the microbiome may be used as a prognostic biomarker and may also explain the pathogenesis of interstitial fibrosis.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1240&context=jmmslung microbiomepulmonary diseasesidiopathic pulmonary fibrosis |
| spellingShingle | Victoria Maria Ruta Teodora Gabriela Alexescu Ana Rodica Ungur Milena Adina Man Victoria Georgiana Sfirlea Iulia Olimpia Pfingstgraf Nicoleta Motoc Carmen Monica Pop Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis Journal of Mind and Medical Sciences lung microbiome pulmonary diseases idiopathic pulmonary fibrosis |
| title | Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis |
| title_full | Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis |
| title_fullStr | Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis |
| title_full_unstemmed | Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis |
| title_short | Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis |
| title_sort | composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis |
| topic | lung microbiome pulmonary diseases idiopathic pulmonary fibrosis |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1240&context=jmms |
| work_keys_str_mv | AT victoriamariaruta compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT teodoragabrielaalexescu compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT anarodicaungur compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT milenaadinaman compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT victoriageorgianasfirlea compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT iuliaolimpiapfingstgraf compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT nicoletamotoc compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis AT carmenmonicapop compositionandmodificationofthelungmicrobiomeinpatientswithidiopathicpulmonaryfibrosis |