Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality
Background: De novo post-transplant diabetes mellitus (PTDM) is a frequent complication among renal transplant recipients; it confers a high risk for graft failure and patient mortality. This single-centre study aimed to determine the incidence and risk factors of PTDM and its effects on graft outco...
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Knowledge E
2023-08-01
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| Series: | Dubai Diabetes and Endocrinology Journal |
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| Online Access: | https://beta.karger.com/Article/FullText/531665 |
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| author | Dileep Kumar Kashif Gulzar Fakhriya J. Alalawi Ayman Aly Seddik Hind Alnour Maseer Ahmed Sima Najad Hussein Yousif Mohamed Hussain Railey Amna Khalifa Alhadari |
| author_facet | Dileep Kumar Kashif Gulzar Fakhriya J. Alalawi Ayman Aly Seddik Hind Alnour Maseer Ahmed Sima Najad Hussein Yousif Mohamed Hussain Railey Amna Khalifa Alhadari |
| author_sort | Dileep Kumar |
| collection | DOAJ |
| description | Background: De novo post-transplant diabetes mellitus (PTDM) is a frequent complication among renal transplant recipients; it confers a high risk for graft failure and patient mortality. This single-centre study aimed to determine the incidence and risk factors of PTDM and its effects on graft outcome and mortality. Methods: In a single-centre longitudinal cohort analysis of 383 non-diabetic renal transplant follow-up recipients, outcomes were analysed through a detailed chart review. We hypothesized that different donor and recipient characters such as age, gender, and HLA mismatch would affect PTDM development in renal transplant recipients. PTDM is defined on basis of fasting plasma sugar (≥7 mmol/L or ≥126 mg/dL), random plasma sugar (≥11.1 mmol/L or ≥200 mg/dL), and glycated haemoglobin (HBA1C: >6.5% or 48 mmol/mol). We assessed PTDM incidence, risk factors, and its effect on patient mortality and graft outcome using Cox regression. Results: The mean age at the time of transplantation was 35.70 (±14.27) years, and 50.91% were male. PTDM incidence in the study period was 23.30%. Independent risk factors include older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus infection. PTDM is not associated with graft dysfunction, whereas it significantly carries high mortality. Conclusion: PTDM is common among renal transplant recipients. Older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus are risk factors. PTDM carries high mortality but is not associated with graft failure. |
| format | Article |
| id | doaj-art-d3f5b8325691420d94669c50b603de9e |
| institution | DOAJ |
| issn | 2673-1738 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Dubai Diabetes and Endocrinology Journal |
| spelling | doaj-art-d3f5b8325691420d94669c50b603de9e2025-08-20T02:56:27ZengKnowledge EDubai Diabetes and Endocrinology Journal2673-17382023-08-011810.1159/000531665531665Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and MortalityDileep Kumar0https://orcid.org/0000-0002-7363-2661Kashif Gulzar1Fakhriya J. Alalawi2Ayman Aly Seddik3Hind Alnour4Maseer Ahmed5Sima Najad6Hussein Yousif7Mohamed Hussain Railey8Amna Khalifa Alhadari9Department of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, AIN Shams University, Cairo, EgyptDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, Shaikh Khalifa Medical City, Ajman, United Arab EmiratesDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesDepartment of Nephrology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab EmiratesBackground: De novo post-transplant diabetes mellitus (PTDM) is a frequent complication among renal transplant recipients; it confers a high risk for graft failure and patient mortality. This single-centre study aimed to determine the incidence and risk factors of PTDM and its effects on graft outcome and mortality. Methods: In a single-centre longitudinal cohort analysis of 383 non-diabetic renal transplant follow-up recipients, outcomes were analysed through a detailed chart review. We hypothesized that different donor and recipient characters such as age, gender, and HLA mismatch would affect PTDM development in renal transplant recipients. PTDM is defined on basis of fasting plasma sugar (≥7 mmol/L or ≥126 mg/dL), random plasma sugar (≥11.1 mmol/L or ≥200 mg/dL), and glycated haemoglobin (HBA1C: >6.5% or 48 mmol/mol). We assessed PTDM incidence, risk factors, and its effect on patient mortality and graft outcome using Cox regression. Results: The mean age at the time of transplantation was 35.70 (±14.27) years, and 50.91% were male. PTDM incidence in the study period was 23.30%. Independent risk factors include older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus infection. PTDM is not associated with graft dysfunction, whereas it significantly carries high mortality. Conclusion: PTDM is common among renal transplant recipients. Older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus are risk factors. PTDM carries high mortality but is not associated with graft failure.https://beta.karger.com/Article/FullText/531665immunosuppressantprednisolonecyclosporinecytomegalovirushepatitis c virustransplantpost-transplant diabetes mellitus |
| spellingShingle | Dileep Kumar Kashif Gulzar Fakhriya J. Alalawi Ayman Aly Seddik Hind Alnour Maseer Ahmed Sima Najad Hussein Yousif Mohamed Hussain Railey Amna Khalifa Alhadari Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality Dubai Diabetes and Endocrinology Journal immunosuppressant prednisolone cyclosporine cytomegalovirus hepatitis c virus transplant post-transplant diabetes mellitus |
| title | Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality |
| title_full | Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality |
| title_fullStr | Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality |
| title_full_unstemmed | Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality |
| title_short | Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality |
| title_sort | post transplant diabetes mellitus in renal transplant recipients single centre data incidence risk factors and effect on graft function and mortality |
| topic | immunosuppressant prednisolone cyclosporine cytomegalovirus hepatitis c virus transplant post-transplant diabetes mellitus |
| url | https://beta.karger.com/Article/FullText/531665 |
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