Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis
Introduction Gastro-oesophageal reflux is common in patients with oesophagogastric junction (OGJ) cancer following radical surgery. We aim to conduct a systematic review to investigate the effectiveness and clinical value of additional antireflux surgery (pyloroplasty and fundoplication) for OGJ can...
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e066061.full |
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| author | Yang Yu Hao Chen Yu Li Lei Gao Na Wang Peng Zheng Fanghui Ding Bofang Wang |
| author_facet | Yang Yu Hao Chen Yu Li Lei Gao Na Wang Peng Zheng Fanghui Ding Bofang Wang |
| author_sort | Yang Yu |
| collection | DOAJ |
| description | Introduction Gastro-oesophageal reflux is common in patients with oesophagogastric junction (OGJ) cancer following radical surgery. We aim to conduct a systematic review to investigate the effectiveness and clinical value of additional antireflux surgery (pyloroplasty and fundoplication) for OGJ cancer.Methods and analysis We intend to search Medline, Cochrane Library and Embase databases for studies published in English, from database inception to October 2022. Randomised controlled trials and (non-random) controlled clinical trials will be eligible for inclusion. We will search for all eligible studies that have compared proximal gastrectomy plus additional antireflux surgery and proximal gastrectomy alone in patients with resectable OGJ cancer. All potential outcomes related to gastro-oesophageal reflux, including occurrence of reflux symptoms, reflux oesophagitis, reflux occurrence based on barium meal examination, pH of fluid from the lower oesophagus, and 24-hour oesophageal pH test will be assessed as the primary outcomes. Other outcomes, such as patients’ survival and postoperative complications (eg, stenosis, infection and leak) will also be analysed. Two reviewers will independently screen the literature, extract data and assess the risk of bias in the included studies; subsequently, a meta-analysis will be performed using RevMan V.5.3 software to pool the results. The χ2 and I2 tests will be used for heterogeneity assessment and sources of heterogeneity will be explored using subgroup analysis. The Grading of Recommendations, Assessment, Development and Evaluation method will be applied to assess the level of evidence.Ethics and dissemination This proposed study is a secondary analysis of previously published data. Therefore, ethics approval is not required. The results will be presented for publication in a peer-reviewed journal and data will be stored in public databases. |
| format | Article |
| id | doaj-art-d3f5009310b4494d8eecf085172016b8 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d3f5009310b4494d8eecf085172016b82025-08-20T02:11:29ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-066061Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysisYang Yu0Hao Chen1Yu Li2Lei Gao3Na Wang4Peng Zheng5Fanghui Ding6Bofang Wang72 National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Anesthesiology, Wenzhou Central Hospital, Wenzhou, Zhejiang, China7 Weifang Eye Hospital, Shandong, ChinaKey Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, ChinaGeneral Surgery Department, First Hospital of Lanzhou University, Lanzhou, ChinaGeneral Surgery Department, First Hospital of Lanzhou University, Lanzhou, ChinaThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, ChinaIntroduction Gastro-oesophageal reflux is common in patients with oesophagogastric junction (OGJ) cancer following radical surgery. We aim to conduct a systematic review to investigate the effectiveness and clinical value of additional antireflux surgery (pyloroplasty and fundoplication) for OGJ cancer.Methods and analysis We intend to search Medline, Cochrane Library and Embase databases for studies published in English, from database inception to October 2022. Randomised controlled trials and (non-random) controlled clinical trials will be eligible for inclusion. We will search for all eligible studies that have compared proximal gastrectomy plus additional antireflux surgery and proximal gastrectomy alone in patients with resectable OGJ cancer. All potential outcomes related to gastro-oesophageal reflux, including occurrence of reflux symptoms, reflux oesophagitis, reflux occurrence based on barium meal examination, pH of fluid from the lower oesophagus, and 24-hour oesophageal pH test will be assessed as the primary outcomes. Other outcomes, such as patients’ survival and postoperative complications (eg, stenosis, infection and leak) will also be analysed. Two reviewers will independently screen the literature, extract data and assess the risk of bias in the included studies; subsequently, a meta-analysis will be performed using RevMan V.5.3 software to pool the results. The χ2 and I2 tests will be used for heterogeneity assessment and sources of heterogeneity will be explored using subgroup analysis. The Grading of Recommendations, Assessment, Development and Evaluation method will be applied to assess the level of evidence.Ethics and dissemination This proposed study is a secondary analysis of previously published data. Therefore, ethics approval is not required. The results will be presented for publication in a peer-reviewed journal and data will be stored in public databases.https://bmjopen.bmj.com/content/12/12/e066061.full |
| spellingShingle | Yang Yu Hao Chen Yu Li Lei Gao Na Wang Peng Zheng Fanghui Ding Bofang Wang Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis BMJ Open |
| title | Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis |
| title_full | Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis |
| title_fullStr | Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis |
| title_short | Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis |
| title_sort | effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/12/e066061.full |
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