The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction
Abstract Background Heart failure poses a huge burden on the global population, and approximately 50% cases have reduced ejection fraction, namely, heart failure with reduced ejection fraction (HFrEF). The research was supposed to explore the relationship between serum hsa-miR-21-5p expression and t...
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BMC
2025-02-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04465-y |
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| author | Lingmiao Wang Ailin Guo Shuang Liang Lingling Yu Bai Shen Zhihang Huang |
| author_facet | Lingmiao Wang Ailin Guo Shuang Liang Lingling Yu Bai Shen Zhihang Huang |
| author_sort | Lingmiao Wang |
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| description | Abstract Background Heart failure poses a huge burden on the global population, and approximately 50% cases have reduced ejection fraction, namely, heart failure with reduced ejection fraction (HFrEF). The research was supposed to explore the relationship between serum hsa-miR-21-5p expression and the severity/prognosis of HFrEF. Methods A retrospective analysis was conducted on 105 HFrEF patients and 86 healthy volunteers. RT-qPCR was used for the detection of serum hsa-miR-21-5p levels. Whether serum hsa-miR-21-5p expression correlated to cardiac function and hemodynamic indicators was evaluated using Spearman correlation analysis. Receiver operating characteristic and Kaplan-Meier analyses were implemented to evaluate the predictive significance of serum hsa-miR-21-5p for cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients. Independent risk factors for cardiovascular deaths were analyzed based on COX regression. Results Higher heart rate, fasting plasma glucose (FPG), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), left atrial diameter (LAD), systolic pulmonary artery pressure (sPAP), pulmonary vascular resistance (PVR), pulmonary capillary wedge pressure (PCWP), and hsa-miR-21-5p as well as lower left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were detected in the HFrEF patients than in the controls. Hsa-miR-21-5p expression increased in HFrEF patients with the increase of NYHA grade. Serum hsa-miR-21-5p expression in HFrEF patients was positively relevant to NT-pro-BNP, LAD, sPAP, PVR, and PCWP but negatively related to LVEF and LVFS. Serum hsa-miR-21-5p had a high predictive value for cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients. High hsa-miR-21-5p expression was an independent dangerous factor for cardiovascular deaths. Conclusion Collectively, hsa-miR-21-5p expression in HFrEF patients is correlated with disease severity and the risk of cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients, indicating a new direction for evaluating the disease situation and prognosis. |
| format | Article |
| id | doaj-art-d3f0f2542e6445f59fe35ca61b087f84 |
| institution | OA Journals |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-d3f0f2542e6445f59fe35ca61b087f842025-08-20T02:15:07ZengBMCBMC Cardiovascular Disorders1471-22612025-02-0125111110.1186/s12872-024-04465-yThe association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fractionLingmiao Wang0Ailin Guo1Shuang Liang2Lingling Yu3Bai Shen4Zhihang Huang5Department of Anesthesiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Cardiovascular Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Cardiovascular Medicine, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Cardiovascular Medicine, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Cardiovascular Medicine, Dongguan Songshan Lake Central Hospital, Dongguan Institute of Cardiovascular DiseaseDepartment of Cardiovascular Medicine, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract Background Heart failure poses a huge burden on the global population, and approximately 50% cases have reduced ejection fraction, namely, heart failure with reduced ejection fraction (HFrEF). The research was supposed to explore the relationship between serum hsa-miR-21-5p expression and the severity/prognosis of HFrEF. Methods A retrospective analysis was conducted on 105 HFrEF patients and 86 healthy volunteers. RT-qPCR was used for the detection of serum hsa-miR-21-5p levels. Whether serum hsa-miR-21-5p expression correlated to cardiac function and hemodynamic indicators was evaluated using Spearman correlation analysis. Receiver operating characteristic and Kaplan-Meier analyses were implemented to evaluate the predictive significance of serum hsa-miR-21-5p for cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients. Independent risk factors for cardiovascular deaths were analyzed based on COX regression. Results Higher heart rate, fasting plasma glucose (FPG), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), left atrial diameter (LAD), systolic pulmonary artery pressure (sPAP), pulmonary vascular resistance (PVR), pulmonary capillary wedge pressure (PCWP), and hsa-miR-21-5p as well as lower left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were detected in the HFrEF patients than in the controls. Hsa-miR-21-5p expression increased in HFrEF patients with the increase of NYHA grade. Serum hsa-miR-21-5p expression in HFrEF patients was positively relevant to NT-pro-BNP, LAD, sPAP, PVR, and PCWP but negatively related to LVEF and LVFS. Serum hsa-miR-21-5p had a high predictive value for cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients. High hsa-miR-21-5p expression was an independent dangerous factor for cardiovascular deaths. Conclusion Collectively, hsa-miR-21-5p expression in HFrEF patients is correlated with disease severity and the risk of cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients, indicating a new direction for evaluating the disease situation and prognosis.https://doi.org/10.1186/s12872-024-04465-yHeart failure with reduced ejection fractionHsa-miR-21-5pDisease severityNYHA gradePrognosisCardiac function |
| spellingShingle | Lingmiao Wang Ailin Guo Shuang Liang Lingling Yu Bai Shen Zhihang Huang The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction BMC Cardiovascular Disorders Heart failure with reduced ejection fraction Hsa-miR-21-5p Disease severity NYHA grade Prognosis Cardiac function |
| title | The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction |
| title_full | The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction |
| title_fullStr | The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction |
| title_full_unstemmed | The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction |
| title_short | The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction |
| title_sort | association of serum hsa mir 21 5p expression with the severity and prognosis of heart failure with reduced ejection fraction |
| topic | Heart failure with reduced ejection fraction Hsa-miR-21-5p Disease severity NYHA grade Prognosis Cardiac function |
| url | https://doi.org/10.1186/s12872-024-04465-y |
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