Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis
Characteristics of the clinical process and immunological profile in children with yersiniosis as a monoinfection or in association with acute intenstinal infections and virus hepatitis A are presented. The efficacy of the immunotropic therapy with cycloferon, an interferon inductor, and recombinant...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/378 |
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| author | A. V. Gordeets E. N. Yurusova A. N. Smagina S. L. Piskunova |
| author_facet | A. V. Gordeets E. N. Yurusova A. N. Smagina S. L. Piskunova |
| author_sort | A. V. Gordeets |
| collection | DOAJ |
| description | Characteristics of the clinical process and immunological profile in children with yersiniosis as a monoinfection or in association with acute intenstinal infections and virus hepatitis A are presented. The efficacy of the immunotropic therapy with cycloferon, an interferon inductor, and recombinant interferon in the patients with the viral and bacterial association of the disease (yersiniosis + hepatitis A) and initial disbalance of the serum cytokines was estimated. Dependence of the interferon clinicolaboratory efficacy on the initial levels of serum γ-interferon, IL2 and IL4, promoting shorter terms of hyperthermia, diarrhea syndrome and cytolysis syndrome was shown. It allowed to optimize the scheme of the pathogenetic therapy of Yersinia mixed infection. |
| format | Article |
| id | doaj-art-d3ee8a9197e14c5695ed7652ed03bb82 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-d3ee8a9197e14c5695ed7652ed03bb822025-08-20T02:49:35ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01565-64953377Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of YersiniosisA. V. Gordeets0E. N. Yurusova1A. N. Smagina2S. L. Piskunova3Vladivostok State Medical UniversityVladivostok State Medical UniversityI.P. Pavlov St.Petersburg State Medical UniversityMunicipal Clinical Hospital No. 2, VladivostokCharacteristics of the clinical process and immunological profile in children with yersiniosis as a monoinfection or in association with acute intenstinal infections and virus hepatitis A are presented. The efficacy of the immunotropic therapy with cycloferon, an interferon inductor, and recombinant interferon in the patients with the viral and bacterial association of the disease (yersiniosis + hepatitis A) and initial disbalance of the serum cytokines was estimated. Dependence of the interferon clinicolaboratory efficacy on the initial levels of serum γ-interferon, IL2 and IL4, promoting shorter terms of hyperthermia, diarrhea syndrome and cytolysis syndrome was shown. It allowed to optimize the scheme of the pathogenetic therapy of Yersinia mixed infection.https://www.antibiotics-chemotherapy.ru/jour/article/view/378yersiniosismixed infectioncytokinescycloferon |
| spellingShingle | A. V. Gordeets E. N. Yurusova A. N. Smagina S. L. Piskunova Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis Антибиотики и Химиотерапия yersiniosis mixed infection cytokines cycloferon |
| title | Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis |
| title_full | Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis |
| title_fullStr | Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis |
| title_full_unstemmed | Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis |
| title_short | Clinicoimmunological Monitoring of Therapy in Patients with Associated Forms of Yersiniosis |
| title_sort | clinicoimmunological monitoring of therapy in patients with associated forms of yersiniosis |
| topic | yersiniosis mixed infection cytokines cycloferon |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/378 |
| work_keys_str_mv | AT avgordeets clinicoimmunologicalmonitoringoftherapyinpatientswithassociatedformsofyersiniosis AT enyurusova clinicoimmunologicalmonitoringoftherapyinpatientswithassociatedformsofyersiniosis AT ansmagina clinicoimmunologicalmonitoringoftherapyinpatientswithassociatedformsofyersiniosis AT slpiskunova clinicoimmunologicalmonitoringoftherapyinpatientswithassociatedformsofyersiniosis |