The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy
It is uncertain whether small vessel disease underlies the relationship between Type 2 Diabetes Mellitus (T2DM) and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes....
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6328953 |
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| author | C. Moran R. J. Tapp A. D. Hughes C. G. Magnussen L. Blizzard T. G. Phan R. Beare N. Witt A. Venn G. Münch B. C. Amaratunge V. Srikanth |
| author_facet | C. Moran R. J. Tapp A. D. Hughes C. G. Magnussen L. Blizzard T. G. Phan R. Beare N. Witt A. Venn G. Münch B. C. Amaratunge V. Srikanth |
| author_sort | C. Moran |
| collection | DOAJ |
| description | It is uncertain whether small vessel disease underlies the relationship between Type 2 Diabetes Mellitus (T2DM) and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI) scans and retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular architecture, clinical retinopathy, and MRI cerebrovascular lesions. There were 270 people with (mean age 67.3 years) and 181 without T2DM (mean age 72.9 years). T2DM was associated with lower gray matter volume (p=0.008). T2DM was associated with greater arteriolar diameter (p=0.03) and optimality ratio (p=0.04), but these associations were attenuated by adjustments for age and sex. Only optimality ratio was associated with lower gray matter volume (p=0.03). The inclusion of retinal measures in regression models did not attenuate the association of T2DM with gray matter volume. The association of T2DM with lower gray matter volume was independent of retinal vascular architecture and clinical retinopathy. Retinal vascular measures or retinopathy may not be sufficiently sensitive to confirm a microvascular basis for T2DM-related brain atrophy. |
| format | Article |
| id | doaj-art-d3ebfe76e4c74aa89717b5af9f5c887c |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d3ebfe76e4c74aa89717b5af9f5c887c2025-08-20T02:19:45ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/63289536328953The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and RetinopathyC. Moran0R. J. Tapp1A. D. Hughes2C. G. Magnussen3L. Blizzard4T. G. Phan5R. Beare6N. Witt7A. Venn8G. Münch9B. C. Amaratunge10V. Srikanth11Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC 3168, AustraliaMelbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3010, AustraliaInternational Centre for Circulatory Health, National Heart and Lung Institute, St Mary’s Hospital and Imperial College, London SW7 2AZ, UKMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, AustraliaStroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC 3168, AustraliaStroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC 3168, AustraliaInternational Centre for Circulatory Health, National Heart and Lung Institute, St Mary’s Hospital and Imperial College, London SW7 2AZ, UKMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, AustraliaDepartment of Pharmacology and Molecular Medicine Research Group, School of Medicine, University of Western Sydney, Campbelltown, NSW 2753, AustraliaRoyal Victorian Eye and Ear Hospital, Melbourne, VIC 7000, AustraliaStroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC 3168, AustraliaIt is uncertain whether small vessel disease underlies the relationship between Type 2 Diabetes Mellitus (T2DM) and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI) scans and retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular architecture, clinical retinopathy, and MRI cerebrovascular lesions. There were 270 people with (mean age 67.3 years) and 181 without T2DM (mean age 72.9 years). T2DM was associated with lower gray matter volume (p=0.008). T2DM was associated with greater arteriolar diameter (p=0.03) and optimality ratio (p=0.04), but these associations were attenuated by adjustments for age and sex. Only optimality ratio was associated with lower gray matter volume (p=0.03). The inclusion of retinal measures in regression models did not attenuate the association of T2DM with gray matter volume. The association of T2DM with lower gray matter volume was independent of retinal vascular architecture and clinical retinopathy. Retinal vascular measures or retinopathy may not be sufficiently sensitive to confirm a microvascular basis for T2DM-related brain atrophy.http://dx.doi.org/10.1155/2016/6328953 |
| spellingShingle | C. Moran R. J. Tapp A. D. Hughes C. G. Magnussen L. Blizzard T. G. Phan R. Beare N. Witt A. Venn G. Münch B. C. Amaratunge V. Srikanth The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy Journal of Diabetes Research |
| title | The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy |
| title_full | The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy |
| title_fullStr | The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy |
| title_full_unstemmed | The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy |
| title_short | The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy |
| title_sort | association of type 2 diabetes mellitus with cerebral gray matter volume is independent of retinal vascular architecture and retinopathy |
| url | http://dx.doi.org/10.1155/2016/6328953 |
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