Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain
Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as micro...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/9383184 |
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| author | Temugin Berta Jee Eun Lee Chul-Kyu Park |
| author_facet | Temugin Berta Jee Eun Lee Chul-Kyu Park |
| author_sort | Temugin Berta |
| collection | DOAJ |
| description | Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as microglia, and inflammatory signaling play a major role in the pathogenesis of chronic pain. Caspases (CASPs) are a family of protease enzymes involved in apoptosis and inflammation. They are pivotal components in a variety of neurological diseases. However, little is known about the role of CASPs in microglial modulation as to chronic pain. In particular, our recent studies have shown that CASP6 regulates chronic pain via microglial inflammatory signaling. Inhibition of microglia and CASP signaling might provide a new strategy for the prevention and treatment of chronic pain. |
| format | Article |
| id | doaj-art-d3ebc9d19722470c8a08a6d92e59df7b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d3ebc9d19722470c8a08a6d92e59df7b2025-08-20T03:24:14ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/93831849383184Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic PainTemugin Berta0Jee Eun Lee1Chul-Kyu Park2Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, OH, USADepartment of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of KoreaDepartment of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of KoreaChronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as microglia, and inflammatory signaling play a major role in the pathogenesis of chronic pain. Caspases (CASPs) are a family of protease enzymes involved in apoptosis and inflammation. They are pivotal components in a variety of neurological diseases. However, little is known about the role of CASPs in microglial modulation as to chronic pain. In particular, our recent studies have shown that CASP6 regulates chronic pain via microglial inflammatory signaling. Inhibition of microglia and CASP signaling might provide a new strategy for the prevention and treatment of chronic pain.http://dx.doi.org/10.1155/2017/9383184 |
| spellingShingle | Temugin Berta Jee Eun Lee Chul-Kyu Park Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain Mediators of Inflammation |
| title | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
| title_full | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
| title_fullStr | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
| title_full_unstemmed | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
| title_short | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
| title_sort | unconventional role of caspase 6 in spinal microglia activation and chronic pain |
| url | http://dx.doi.org/10.1155/2017/9383184 |
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