Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis
Purpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG). Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the po...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/1348347 |
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| author | Yang Xiang Yi Dong Xuan Li Xin Tang |
| author_facet | Yang Xiang Yi Dong Xuan Li Xin Tang |
| author_sort | Yang Xiang |
| collection | DOAJ |
| description | Purpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG). Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if I2<50% in the test for heterogeneity; otherwise the random-effects model was used. Results. Thirty-one records were obtained, with five being suitable for meta-analysis. The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility. Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians. Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group. Conclusions. TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group. |
| format | Article |
| id | doaj-art-d3eb039fd1d84302aabf1f22c78115dc |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-d3eb039fd1d84302aabf1f22c78115dc2025-08-20T02:19:45ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/13483471348347Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-AnalysisYang Xiang0Yi Dong1Xuan Li2Xin Tang3Clinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, ChinaPurpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG). Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if I2<50% in the test for heterogeneity; otherwise the random-effects model was used. Results. Thirty-one records were obtained, with five being suitable for meta-analysis. The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility. Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians. Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group. Conclusions. TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group.http://dx.doi.org/10.1155/2016/1348347 |
| spellingShingle | Yang Xiang Yi Dong Xuan Li Xin Tang Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis Journal of Ophthalmology |
| title | Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis |
| title_full | Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis |
| title_fullStr | Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis |
| title_full_unstemmed | Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis |
| title_short | Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis |
| title_sort | association of common variants in enos gene with primary open angle glaucoma a meta analysis |
| url | http://dx.doi.org/10.1155/2016/1348347 |
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