Innate Anti-Candidal Immunity and Evasive Strategies.
Candidiasis, an opportunistic infection commonly caused by the polymorphic commensal fungal agent, Candida albicans yielding a spectrum of infection from mild superficial infection to invasive disseminated disease. The systemic candidiasis occurs widely among immunocompromised patients with mostly f...
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| Format: | Article |
| Language: | English |
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Hammer Head Production Limited
2020-06-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
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| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/133 |
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| author | Aliyu, M. , Sharif, A.A. , Getso, M.I. , Mohammed, Y. , Adamu, A.Y , Takalmawa, H.U., Daneji, M.I. , and Jibril, M.* |
| author_facet | Aliyu, M. , Sharif, A.A. , Getso, M.I. , Mohammed, Y. , Adamu, A.Y , Takalmawa, H.U., Daneji, M.I. , and Jibril, M.* |
| author_sort | Aliyu, M. , Sharif, A.A. , Getso, M.I. , Mohammed, Y. , Adamu, A.Y , Takalmawa, H.U., Daneji, M.I. , and Jibril, M.* |
| collection | DOAJ |
| description | Candidiasis, an opportunistic infection commonly caused by the polymorphic commensal fungal agent, Candida albicans yielding a spectrum of infection from mild superficial infection to invasive disseminated disease. The systemic candidiasis occurs widely among
immunocompromised patients with mostly fatal outcomes. Candida survived with us from birth to death, predominantly in symbiotic settings on the skin and mucosal surfaces. But in the presence of compromised immune systems from varying causes or when the Candida trooped outside its usual confinement, then they become opportunistic and cause severe disease. The resultant systemic spread is expensive to manage, allowing short response time before conceding a mortal score. The systemic candidiasis carries high mortality even in the most advanced settings. Despite extensive research, candidiasis remains a significant health problem globally. The host immune system at various levels uses pattern recognition receptors (PRRs) to identify candidal pathogen-associated molecular patterns (PAMPs). The defense aim at control using barriers, phagocytosis, secretory antimicrobial peptides (AMPs),
complements, neutrophil extracellular traps (NETs), and the like. Of note, Candida devises a multitude of ways to overcome virtually all the protective strategies of the human host defense. Candida evades the host immune system using an array of mechanisms to establish infection. Evasive modalities include proteolytic enzymes, nutrient scavenging, and free radicals’ detoxification. Other methods involved concealment of PAMPs through shape shifting, diverting candidal recognition towards the production of anti-inflammatory cytokines. Here we review some of these host-pathogen interactions to aid the development of immunotherapies. |
| format | Article |
| id | doaj-art-d3e49a17f6a9410d8ea57dd9e4f9f3ba |
| institution | Kabale University |
| issn | 2536-7153 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-d3e49a17f6a9410d8ea57dd9e4f9f3ba2025-08-20T03:42:35ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532020-06-0152133Innate Anti-Candidal Immunity and Evasive Strategies.Aliyu, M. , Sharif, A.A. , Getso, M.I. , Mohammed, Y. , Adamu, A.Y , Takalmawa, H.U., Daneji, M.I. , and Jibril, M.*Candidiasis, an opportunistic infection commonly caused by the polymorphic commensal fungal agent, Candida albicans yielding a spectrum of infection from mild superficial infection to invasive disseminated disease. The systemic candidiasis occurs widely among immunocompromised patients with mostly fatal outcomes. Candida survived with us from birth to death, predominantly in symbiotic settings on the skin and mucosal surfaces. But in the presence of compromised immune systems from varying causes or when the Candida trooped outside its usual confinement, then they become opportunistic and cause severe disease. The resultant systemic spread is expensive to manage, allowing short response time before conceding a mortal score. The systemic candidiasis carries high mortality even in the most advanced settings. Despite extensive research, candidiasis remains a significant health problem globally. The host immune system at various levels uses pattern recognition receptors (PRRs) to identify candidal pathogen-associated molecular patterns (PAMPs). The defense aim at control using barriers, phagocytosis, secretory antimicrobial peptides (AMPs), complements, neutrophil extracellular traps (NETs), and the like. Of note, Candida devises a multitude of ways to overcome virtually all the protective strategies of the human host defense. Candida evades the host immune system using an array of mechanisms to establish infection. Evasive modalities include proteolytic enzymes, nutrient scavenging, and free radicals’ detoxification. Other methods involved concealment of PAMPs through shape shifting, diverting candidal recognition towards the production of anti-inflammatory cytokines. Here we review some of these host-pathogen interactions to aid the development of immunotherapies.https://sokjmls.com.ng/index.php/SJMLS/article/view/133candida albicans, candidiasis, phagocytosis, antimicrobial peptides, innate immune response, immune evasion. |
| spellingShingle | Aliyu, M. , Sharif, A.A. , Getso, M.I. , Mohammed, Y. , Adamu, A.Y , Takalmawa, H.U., Daneji, M.I. , and Jibril, M.* Innate Anti-Candidal Immunity and Evasive Strategies. Sokoto Journal of Medical Laboratory Science candida albicans, candidiasis, phagocytosis, antimicrobial peptides, innate immune response, immune evasion. |
| title | Innate Anti-Candidal Immunity and Evasive Strategies. |
| title_full | Innate Anti-Candidal Immunity and Evasive Strategies. |
| title_fullStr | Innate Anti-Candidal Immunity and Evasive Strategies. |
| title_full_unstemmed | Innate Anti-Candidal Immunity and Evasive Strategies. |
| title_short | Innate Anti-Candidal Immunity and Evasive Strategies. |
| title_sort | innate anti candidal immunity and evasive strategies |
| topic | candida albicans, candidiasis, phagocytosis, antimicrobial peptides, innate immune response, immune evasion. |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/133 |
| work_keys_str_mv | AT aliyumsharifaagetsomimohammedyadamuaytakalmawahudanejimiandjibrilm innateanticandidalimmunityandevasivestrategies |