Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital
Objective: To correlate serum levels of YKL-40 with anthropometric measurements and spirometric indices between normal individuals and asthmatics. Methodology: The case control study was conducted in Department of Chest Medicine, JPMC, Karachi from the month of August 2015 till March 2016. The stud...
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Bahria Univerisy Health Sciences, Campus Karachi
2021-03-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/496 |
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| author | Syeda Nargis Fatima Fatima Ali Khan Jawed Iqbal |
| author_facet | Syeda Nargis Fatima Fatima Ali Khan Jawed Iqbal |
| author_sort | Syeda Nargis Fatima |
| collection | DOAJ |
| description |
Objective: To correlate serum levels of YKL-40 with anthropometric measurements and spirometric indices between
normal individuals and asthmatics.
Methodology: The case control study was conducted in Department of Chest Medicine, JPMC, Karachi from the month
of August 2015 till March 2016. The study recruited sixty participants after satisfying the inclusion and exclusion criteria;
among those 30 were normal healthy individuals (PEF > 80% and pulse rate of 60 – 80 beats per minutes); while equal
were cases of mild to moderate asthma (PEF more than 50% and pulse rate of 100 – 120 beats per minutes) matched for
age and gender. Vitallograph compacta and peak flow meter was used for spirometric indices. Moreover, anthropometric
measurements were age, gender, weight (kg), height (m) and body mass index (kg/m2). Ykl-40 Elisa kit was used for serum
YKL 40 levels. The data was entered and analysed using SPSS version 21 (IBM, Chicago, IL).
Result: In comparison of Spirometric Evaluation (FEV1, FVC, FEV1/FVC% and PEFR) between control and patients with
mild to moderate asthma. significant difference was found in the mean values of FEV1, FVC, FEV1/FVC and PEFR
between cases and controls. Significant inverse correlation was found between YKL-40 with FEV1, FVC, FEVI/FVC%
and PEFR among Controls. YKL-40 was found to be significantly correlated with only FEV1/ FVC (%) among cases with
correlation co-efficient as – 0.510 (p-value < 0.004).
Conclusion: There is an inverse correlation between serum YKL-40 levels and spirometric evaluation thus as the inflammation
in asthma increases, YKL-40 level upsurges and causes decrease in lung function tests.
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| format | Article |
| id | doaj-art-d3e05b55db534723b1cdaa7e51284441 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-d3e05b55db534723b1cdaa7e512844412025-08-20T03:13:18ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822021-03-018310.51985/JBUMDC2018023Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care HospitalSyeda Nargis FatimaFatima Ali KhanJawed Iqbal Objective: To correlate serum levels of YKL-40 with anthropometric measurements and spirometric indices between normal individuals and asthmatics. Methodology: The case control study was conducted in Department of Chest Medicine, JPMC, Karachi from the month of August 2015 till March 2016. The study recruited sixty participants after satisfying the inclusion and exclusion criteria; among those 30 were normal healthy individuals (PEF > 80% and pulse rate of 60 – 80 beats per minutes); while equal were cases of mild to moderate asthma (PEF more than 50% and pulse rate of 100 – 120 beats per minutes) matched for age and gender. Vitallograph compacta and peak flow meter was used for spirometric indices. Moreover, anthropometric measurements were age, gender, weight (kg), height (m) and body mass index (kg/m2). Ykl-40 Elisa kit was used for serum YKL 40 levels. The data was entered and analysed using SPSS version 21 (IBM, Chicago, IL). Result: In comparison of Spirometric Evaluation (FEV1, FVC, FEV1/FVC% and PEFR) between control and patients with mild to moderate asthma. significant difference was found in the mean values of FEV1, FVC, FEV1/FVC and PEFR between cases and controls. Significant inverse correlation was found between YKL-40 with FEV1, FVC, FEVI/FVC% and PEFR among Controls. YKL-40 was found to be significantly correlated with only FEV1/ FVC (%) among cases with correlation co-efficient as – 0.510 (p-value < 0.004). Conclusion: There is an inverse correlation between serum YKL-40 levels and spirometric evaluation thus as the inflammation in asthma increases, YKL-40 level upsurges and causes decrease in lung function tests. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/496Asthma, YKL-40, anthropometric, spirometric, FEV1, FVC, PEFR |
| spellingShingle | Syeda Nargis Fatima Fatima Ali Khan Jawed Iqbal Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital Journal of Bahria University Medical and Dental College Asthma, YKL-40, anthropometric, spirometric, FEV1, FVC, PEFR |
| title | Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital |
| title_full | Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital |
| title_fullStr | Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital |
| title_full_unstemmed | Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital |
| title_short | Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital |
| title_sort | correlation of serum ykl 40 with anthropometric measurements and spirometric indices between healthy individuals and asthamatics in a tertiary care hospital |
| topic | Asthma, YKL-40, anthropometric, spirometric, FEV1, FVC, PEFR |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/496 |
| work_keys_str_mv | AT syedanargisfatima correlationofserumykl40withanthropometricmeasurementsandspirometricindicesbetweenhealthyindividualsandasthamaticsinatertiarycarehospital AT fatimaalikhan correlationofserumykl40withanthropometricmeasurementsandspirometricindicesbetweenhealthyindividualsandasthamaticsinatertiarycarehospital AT jawediqbal correlationofserumykl40withanthropometricmeasurementsandspirometricindicesbetweenhealthyindividualsandasthamaticsinatertiarycarehospital |