Relevance of Tissue Glue in Cornea Practice
Suturing is not only time-consuming but is associated with complications such as infection, irritation of ocular tissues, and suture granulomas. To circumvent these complications, the use of tissue glues is advocated in select corneal and ocular surface conditions. Two types of tissue glues, synthet...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_177_23 |
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| Summary: | Suturing is not only time-consuming but is associated with complications such as infection, irritation of ocular tissues, and suture granulomas. To circumvent these complications, the use of tissue glues is advocated in select corneal and ocular surface conditions. Two types of tissue glues, synthetic (cyanoacrylate derivatives) and biological (fibrin-based derivatives) are presently available. Cyanoacrylate derivatives have high tensile strength and antibacterial properties and are primarily used to seal small corneal perforations. They are nonbiodegradable, induce inflammatory reaction and neovascularization if left in situ, and are toxic to endothelium and iris. The fibrin-based derivatives on the other hand have low tensile strength, induce minimal inflammation, and are biodegradable. The latter are nontoxic and are well tolerated by ocular tissue but carry a risk of viral transmission. In this review, we discuss in detail the types of tissue glues, their mechanism of action, indications in cornea practice, and newer alternatives. |
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| ISSN: | 0972-0200 2454-2784 |