DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS
Degeneration of the intervertebral disk (IVD) is a pathological process resulting from an interplay between genetic and environmental factors causing structural and functional damage of the IVD and neighboring structures. It is the first stage of degenerative cascade in the vertebral motion segment....
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| Format: | Article |
| Language: | Russian |
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ABV-press
2018-06-01
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| Series: | Klinicist |
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| Online Access: | https://klinitsist.abvpress.ru/Klin/article/view/321 |
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| author | N. G. Pravdyuk N. A. Shostak |
| author_facet | N. G. Pravdyuk N. A. Shostak |
| author_sort | N. G. Pravdyuk |
| collection | DOAJ |
| description | Degeneration of the intervertebral disk (IVD) is a pathological process resulting from an interplay between genetic and environmental factors causing structural and functional damage of the IVD and neighboring structures. It is the first stage of degenerative cascade in the vertebral motion segment. Initiation and progression of IVD degenerative processes traditionally involves several factors: inadequate mechanical load, decreased diffusion of nutrients through the arch laminae, and genetic factors playing a significant role in the development of degenerative changes. Three categories of candidate genes whose coding variants are associated with different forms of degenerative changes in the IVD are identified, a conceptual model of genetic interactions in degenerative disease of the disk is developed. The study of the role of structural changes in back pain genesis, evaluation of risk factors allow to optimize the tactics of patient care and find new therapeutic solutions preventing disease progression. |
| format | Article |
| id | doaj-art-d3d6347723bb465d8cb2a357f2755481 |
| institution | Kabale University |
| issn | 1818-8338 |
| language | Russian |
| publishDate | 2018-06-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Klinicist |
| spelling | doaj-art-d3d6347723bb465d8cb2a357f27554812025-08-20T04:00:43ZrusABV-pressKlinicist1818-83382018-06-01113-4172210.17650/1818-8338-2017-11-3-4-17-22279DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTSN. G. Pravdyuk0N. A. Shostak1N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaDegeneration of the intervertebral disk (IVD) is a pathological process resulting from an interplay between genetic and environmental factors causing structural and functional damage of the IVD and neighboring structures. It is the first stage of degenerative cascade in the vertebral motion segment. Initiation and progression of IVD degenerative processes traditionally involves several factors: inadequate mechanical load, decreased diffusion of nutrients through the arch laminae, and genetic factors playing a significant role in the development of degenerative changes. Three categories of candidate genes whose coding variants are associated with different forms of degenerative changes in the IVD are identified, a conceptual model of genetic interactions in degenerative disease of the disk is developed. The study of the role of structural changes in back pain genesis, evaluation of risk factors allow to optimize the tactics of patient care and find new therapeutic solutions preventing disease progression.https://klinitsist.abvpress.ru/Klin/article/view/321back painintervertebral disk degenerationgenetic polymorphismcandidate genesrisk factorsmicrotraumaobesityinflammationvertebral motion segmentdisk degeneration diseasematrix metalloproteasesaggrecan genecomt gene |
| spellingShingle | N. G. Pravdyuk N. A. Shostak DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS Klinicist back pain intervertebral disk degeneration genetic polymorphism candidate genes risk factors microtrauma obesity inflammation vertebral motion segment disk degeneration disease matrix metalloproteases aggrecan gene comt gene |
| title | DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS |
| title_full | DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS |
| title_fullStr | DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS |
| title_full_unstemmed | DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS |
| title_short | DEGENERATIVE SPINE INJURY ASSOCIATED WITH BACK PAIN: MORPHOGENETIC ASPECTS |
| title_sort | degenerative spine injury associated with back pain morphogenetic aspects |
| topic | back pain intervertebral disk degeneration genetic polymorphism candidate genes risk factors microtrauma obesity inflammation vertebral motion segment disk degeneration disease matrix metalloproteases aggrecan gene comt gene |
| url | https://klinitsist.abvpress.ru/Klin/article/view/321 |
| work_keys_str_mv | AT ngpravdyuk degenerativespineinjuryassociatedwithbackpainmorphogeneticaspects AT nashostak degenerativespineinjuryassociatedwithbackpainmorphogeneticaspects |