Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head
The last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phe...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/8914569 |
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| _version_ | 1850173978127106048 |
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| author | Yi Wang Xibo Ma Wei Chai Jie Tian |
| author_facet | Yi Wang Xibo Ma Wei Chai Jie Tian |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | The last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Bone marrow mesenchymal stem cells and adipose-derived stem cells have demonstrated better effects in the treatment of femoral head necrosis. Various materials have been used widely in the ONFH treatment in both preclinical and clinical trials. In a word, in vivo and multiscale efforts are expected to overcome obstacles in the approaches for treating ONFH and provide clinical relevance and commercial strategies in the future. Therefore, we will discuss the above aspects in this paper and present our opinions. |
| format | Article |
| id | doaj-art-d3d1655ee23e4e34b07546748d5ce632 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d3d1655ee23e4e34b07546748d5ce6322025-08-20T02:19:45ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/89145698914569Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral HeadYi Wang0Xibo Ma1Wei Chai2Jie Tian3Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, ChinaCAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, ChinaDepartment of Orthopedics, Chinese PLA General Hospital, Beijing 100853, ChinaCAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, ChinaThe last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Bone marrow mesenchymal stem cells and adipose-derived stem cells have demonstrated better effects in the treatment of femoral head necrosis. Various materials have been used widely in the ONFH treatment in both preclinical and clinical trials. In a word, in vivo and multiscale efforts are expected to overcome obstacles in the approaches for treating ONFH and provide clinical relevance and commercial strategies in the future. Therefore, we will discuss the above aspects in this paper and present our opinions.http://dx.doi.org/10.1155/2019/8914569 |
| spellingShingle | Yi Wang Xibo Ma Wei Chai Jie Tian Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head Stem Cells International |
| title | Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head |
| title_full | Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head |
| title_fullStr | Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head |
| title_full_unstemmed | Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head |
| title_short | Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head |
| title_sort | multiscale stem cell technologies for osteonecrosis of the femoral head |
| url | http://dx.doi.org/10.1155/2019/8914569 |
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