Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism
Aim: To evaluate the correlation between serum creatinine and thyroid-stimulating hormone (TSH) in patients with primary hypothyroidism. Methods: A cross-sectional study was conducted from October 2022 to April 2024 at Justice K.S. Hegde Charitable Hospital, Nitte. Sixty-two hypothyroid patients wer...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_484_25 |
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| author | Anil Chandra Chethan Subramanya |
| author_facet | Anil Chandra Chethan Subramanya |
| author_sort | Anil Chandra |
| collection | DOAJ |
| description | Aim:
To evaluate the correlation between serum creatinine and thyroid-stimulating hormone (TSH) in patients with primary hypothyroidism.
Methods:
A cross-sectional study was conducted from October 2022 to April 2024 at Justice K.S. Hegde Charitable Hospital, Nitte. Sixty-two hypothyroid patients were included. Clinical data, including serum TSH, creatinine, and eGFR, were analyzed using SPSS 26.0, employing Spearman correlation and Mann–Whitney tests.
Results:
The study included 62 patients (82.3% female, 17.7% male; mean age 43.56 years). Primary hypothyroidism was observed in 61.3%, subclinical in 22.6%, and overt in 16.1%. Mean TSH, creatinine, and eGFR were 9.05 μIU/mL, 0.87 mg/dL, and 85.55 mL/min/1.73m2, respectively. While a positive correlation between TSH and creatinine/eGFR was observed, it was not statistically significant.
Conclusion:
Although TSH showed a positive but nonsignificant correlation with creatinine and eGFR, findings highlight the thyroid–kidney interaction. Further research is needed to assess long-term thyroid effects on renal function. |
| format | Article |
| id | doaj-art-d3ce597a5a564ecb83a7a5acb939b82b |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-d3ce597a5a564ecb83a7a5acb939b82b2025-08-20T02:34:36ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S257S25910.4103/jpbs.jpbs_484_25Correlation of Serum Creatinine with TSH in Patients with Primary HypothyroidismAnil ChandraChethan SubramanyaAim: To evaluate the correlation between serum creatinine and thyroid-stimulating hormone (TSH) in patients with primary hypothyroidism. Methods: A cross-sectional study was conducted from October 2022 to April 2024 at Justice K.S. Hegde Charitable Hospital, Nitte. Sixty-two hypothyroid patients were included. Clinical data, including serum TSH, creatinine, and eGFR, were analyzed using SPSS 26.0, employing Spearman correlation and Mann–Whitney tests. Results: The study included 62 patients (82.3% female, 17.7% male; mean age 43.56 years). Primary hypothyroidism was observed in 61.3%, subclinical in 22.6%, and overt in 16.1%. Mean TSH, creatinine, and eGFR were 9.05 μIU/mL, 0.87 mg/dL, and 85.55 mL/min/1.73m2, respectively. While a positive correlation between TSH and creatinine/eGFR was observed, it was not statistically significant. Conclusion: Although TSH showed a positive but nonsignificant correlation with creatinine and eGFR, findings highlight the thyroid–kidney interaction. Further research is needed to assess long-term thyroid effects on renal function.https://journals.lww.com/10.4103/jpbs.jpbs_484_25correlationcreatinineegfrprimary hypothyroidismtsh |
| spellingShingle | Anil Chandra Chethan Subramanya Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism Journal of Pharmacy and Bioallied Sciences correlation creatinine egfr primary hypothyroidism tsh |
| title | Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism |
| title_full | Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism |
| title_fullStr | Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism |
| title_full_unstemmed | Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism |
| title_short | Correlation of Serum Creatinine with TSH in Patients with Primary Hypothyroidism |
| title_sort | correlation of serum creatinine with tsh in patients with primary hypothyroidism |
| topic | correlation creatinine egfr primary hypothyroidism tsh |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_484_25 |
| work_keys_str_mv | AT anilchandra correlationofserumcreatininewithtshinpatientswithprimaryhypothyroidism AT chethansubramanya correlationofserumcreatininewithtshinpatientswithprimaryhypothyroidism |