ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.

ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has been reported. In this study, we examined t...

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Bibliographic Details
Main Authors: Osamu Sano, Maki Tsujita, Yuji Shimizu, Reiko Kato, Aya Kobayashi, Noriyuki Kioka, Alan T Remaley, Makoto Michikawa, Kazumitsu Ueda, Michinori Matsuo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155400&type=printable
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