Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection

Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N...

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Main Authors: Paulo José Lorenzoni, Cláudia Suemi Kamoi Kay, Rosana Herminia Scola, Hipólito Carraro Júnior, Lineu Cesar Werneck
Format: Article
Language:English
Published: Thieme Revinter Publicações 2012-05-01
Series:Arquivos de Neuro-Psiquiatria
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004&lng=en&tlng=en
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author Paulo José Lorenzoni
Cláudia Suemi Kamoi Kay
Rosana Herminia Scola
Hipólito Carraro Júnior
Lineu Cesar Werneck
author_facet Paulo José Lorenzoni
Cláudia Suemi Kamoi Kay
Rosana Herminia Scola
Hipólito Carraro Júnior
Lineu Cesar Werneck
author_sort Paulo José Lorenzoni
collection DOAJ
description Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection.
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issn 1678-4227
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publisher Thieme Revinter Publicações
record_format Article
series Arquivos de Neuro-Psiquiatria
spelling doaj-art-d3c8262898914f5fb7a38b8bade9397c2025-08-20T03:25:04ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-05-0170532532910.1590/S0004-282X2012000500004S0004-282X2012000500004Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infectionPaulo José Lorenzoni0Cláudia Suemi Kamoi Kay1Rosana Herminia Scola2Hipólito Carraro Júnior3Lineu Cesar Werneck4Universidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáHigher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004&lng=en&tlng=envírus da Influenza A subtipo H1N1creatina quinasebiópsia muscular
spellingShingle Paulo José Lorenzoni
Cláudia Suemi Kamoi Kay
Rosana Herminia Scola
Hipólito Carraro Júnior
Lineu Cesar Werneck
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
Arquivos de Neuro-Psiquiatria
vírus da Influenza A subtipo H1N1
creatina quinase
biópsia muscular
title Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
title_full Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
title_fullStr Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
title_full_unstemmed Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
title_short Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
title_sort muscle biopsy features in critical ill patients with 2009 influenza a h1n1 virus infection
topic vírus da Influenza A subtipo H1N1
creatina quinase
biópsia muscular
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004&lng=en&tlng=en
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