Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study
[Objective] To evaluate the suitability of the existing hemolysis rate standards for locally processed red blood cell components by retrospectively analyzing 5-year hemolysis rate data at the end of storage. [Methods] A total of 720 blood samples of three types of red blood cell components from our...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-06-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.06.013&lang=en |
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| author | LU Zhenping LIU Fufa KANG Meiyan WU Xianbin WANG Yanting LONG Xing QIU Xinlu LI Jin |
| author_facet | LU Zhenping LIU Fufa KANG Meiyan WU Xianbin WANG Yanting LONG Xing QIU Xinlu LI Jin |
| author_sort | LU Zhenping |
| collection | DOAJ |
| description | [Objective] To evaluate the suitability of the existing hemolysis rate standards for locally processed red blood cell components by retrospectively analyzing 5-year hemolysis rate data at the end of storage. [Methods] A total of 720 blood samples of three types of red blood cell components from our blood station from January 2019 to December 2023 were collected. Parameters included hemoglobin concentration (Hb), hematocrit (Hct), and free hemoglobin concentration (fHb). Hemolysis rate were taken as the control standard of 0.8% in accordance with the national standard. The hemolysis rates were compared against the national standard threshold of 0.8% (GB18469-2012), and annual trends of the detection parameters were observed. [Results] The hemolysis rates (x-+s,%) of leukocyte-depleted whole blood at the end of storage were (0.038±0.023 8) in 2019, (0.049±0.039 5) in 2020, (0.043±0.040 7) in 2021, (0.049±0.030 7) in 2022, and (0.058±0.054 8) in 2023, respectively; The hemolysis rates (x-+s" />,%) of leukocyte-depleted suspended red blood cells at the end of storage were (0.093±0.050 2) in 2019, (0.086±0.049 5) in 2020, (0.123±0.072 3) in 2021, (0.122±0.052 1) in 2022, and (0.106±0.058 6) in 2023, respectively; The hemolysis rates (x-+s,%) of washed red blood cells at the end of storage were (0.127±0.038 2) in 2019, (0.150±0.066 5) in 2020, (0.121±0.052 2) in 2021, (0.124±0.038 9) in 2022, and (0.128±0.044 3) in 2023, respectively. [Conclusion] Hemolysis rates at the end of blood storage of three red blood cell components were significantly lower than the limits specified in Quality Requirements for Whole Blood and Components (GB18469-2012), as well as standards from the EU, AABB and the United States. The results demonstrate excellent product quality control. A regional internal control standard of <0.2% is proposed for hemolysis rates at the end of storage. |
| format | Article |
| id | doaj-art-d3c53406ec944f9dad68ac6ca2cefcef |
| institution | DOAJ |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
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| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-d3c53406ec944f9dad68ac6ca2cefcef2025-08-20T02:44:28ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-06-0138682883210.13303/j.cjbt.issn.1004-549x.2025.06.0131004-549X(2025)6-0828-05Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective studyLU Zhenping0LIU Fufa1KANG Meiyan2WU Xianbin3WANG Yanting4LONG Xing5QIU Xinlu6LI Jin7Ganzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, ChinaGanzhou Central Blood Station, Ganzhou 341000, China[Objective] To evaluate the suitability of the existing hemolysis rate standards for locally processed red blood cell components by retrospectively analyzing 5-year hemolysis rate data at the end of storage. [Methods] A total of 720 blood samples of three types of red blood cell components from our blood station from January 2019 to December 2023 were collected. Parameters included hemoglobin concentration (Hb), hematocrit (Hct), and free hemoglobin concentration (fHb). Hemolysis rate were taken as the control standard of 0.8% in accordance with the national standard. The hemolysis rates were compared against the national standard threshold of 0.8% (GB18469-2012), and annual trends of the detection parameters were observed. [Results] The hemolysis rates (x-+s,%) of leukocyte-depleted whole blood at the end of storage were (0.038±0.023 8) in 2019, (0.049±0.039 5) in 2020, (0.043±0.040 7) in 2021, (0.049±0.030 7) in 2022, and (0.058±0.054 8) in 2023, respectively; The hemolysis rates (x-+s" />,%) of leukocyte-depleted suspended red blood cells at the end of storage were (0.093±0.050 2) in 2019, (0.086±0.049 5) in 2020, (0.123±0.072 3) in 2021, (0.122±0.052 1) in 2022, and (0.106±0.058 6) in 2023, respectively; The hemolysis rates (x-+s,%) of washed red blood cells at the end of storage were (0.127±0.038 2) in 2019, (0.150±0.066 5) in 2020, (0.121±0.052 2) in 2021, (0.124±0.038 9) in 2022, and (0.128±0.044 3) in 2023, respectively. [Conclusion] Hemolysis rates at the end of blood storage of three red blood cell components were significantly lower than the limits specified in Quality Requirements for Whole Blood and Components (GB18469-2012), as well as standards from the EU, AABB and the United States. The results demonstrate excellent product quality control. A regional internal control standard of <0.2% is proposed for hemolysis rates at the end of storage.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.06.013&lang=enred blood cell componentshemolysis rate at the end of storagequality standard |
| spellingShingle | LU Zhenping LIU Fufa KANG Meiyan WU Xianbin WANG Yanting LONG Xing QIU Xinlu LI Jin Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study Zhongguo shuxue zazhi red blood cell components hemolysis rate at the end of storage quality standard |
| title | Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study |
| title_full | Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study |
| title_fullStr | Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study |
| title_full_unstemmed | Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study |
| title_short | Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study |
| title_sort | hemolysis rates of three red blood cell components at the end of storage a 5 year retrospective study |
| topic | red blood cell components hemolysis rate at the end of storage quality standard |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.06.013&lang=en |
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