Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies
The purpose of this study was to identify the pseudo spike–wave activation in sleep (SWAS) patterns in the electroencephalogram (EEG) of self-limited focal epilepsies of childhood (SeLFE) and study their clinical and electrical evolution. Sleep EEG and clinical data of children aged 2–12 years with...
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | https://journals.lww.com/10.4103/aian.aian_899_24 |
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| author | Neetha Balaram Smita Balachandran Abdul V Gafoor SR Ratheesh |
| author_facet | Neetha Balaram Smita Balachandran Abdul V Gafoor SR Ratheesh |
| author_sort | Neetha Balaram |
| collection | DOAJ |
| description | The purpose of this study was to identify the pseudo spike–wave activation in sleep (SWAS) patterns in the electroencephalogram (EEG) of self-limited focal epilepsies of childhood (SeLFE) and study their clinical and electrical evolution. Sleep EEG and clinical data of children aged 2–12 years with SeLFE and pseudo-SWAS were collected retrospectively from our EEG database and were followed periodically every 6 months with clinical, EEG, and neurocognitive assessments. Nine children were identified and were grouped as follows: (a) pseudo-SWAS pattern caused by type 1 occipitofrontal spikes in five children, who had no clinical worsening on follow-up, and this pattern resolved within 3 years; (b) pseudo-SWAS pattern without occipitofrontal spikes in three children that was caused by diffusion of pre-existing focal spikes; and (c) pseudo-SWAS pattern induced by antiseizure medication in one child, which completely resolved on withdrawing the medication. Electro-clinical dissociation occurred in pseudo-SWAS, and none of them evolved to developmental and/or epileptic encephalopathy with SWAS. Identification of these patterns helps to avoid inadvertent use of antiseizure medications and immunomodulators. |
| format | Article |
| id | doaj-art-d3bf31b8abd64d6d8bff78f9bf2f178b |
| institution | DOAJ |
| issn | 0972-2327 1998-3549 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj-art-d3bf31b8abd64d6d8bff78f9bf2f178b2025-08-20T02:43:57ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492025-05-0128342643110.4103/aian.aian_899_24Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood EpilepsiesNeetha BalaramSmita BalachandranAbdul V GafoorSR RatheeshThe purpose of this study was to identify the pseudo spike–wave activation in sleep (SWAS) patterns in the electroencephalogram (EEG) of self-limited focal epilepsies of childhood (SeLFE) and study their clinical and electrical evolution. Sleep EEG and clinical data of children aged 2–12 years with SeLFE and pseudo-SWAS were collected retrospectively from our EEG database and were followed periodically every 6 months with clinical, EEG, and neurocognitive assessments. Nine children were identified and were grouped as follows: (a) pseudo-SWAS pattern caused by type 1 occipitofrontal spikes in five children, who had no clinical worsening on follow-up, and this pattern resolved within 3 years; (b) pseudo-SWAS pattern without occipitofrontal spikes in three children that was caused by diffusion of pre-existing focal spikes; and (c) pseudo-SWAS pattern induced by antiseizure medication in one child, which completely resolved on withdrawing the medication. Electro-clinical dissociation occurred in pseudo-SWAS, and none of them evolved to developmental and/or epileptic encephalopathy with SWAS. Identification of these patterns helps to avoid inadvertent use of antiseizure medications and immunomodulators.https://journals.lww.com/10.4103/aian.aian_899_24pseudo-swasseleasselfetype 1 occipitofrontal spikes |
| spellingShingle | Neetha Balaram Smita Balachandran Abdul V Gafoor SR Ratheesh Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies Annals of Indian Academy of Neurology pseudo-swas seleas selfe type 1 occipitofrontal spikes |
| title | Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies |
| title_full | Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies |
| title_fullStr | Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies |
| title_full_unstemmed | Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies |
| title_short | Clinical and Electrical Evolution of “Pseudo” Spike–Wave Activation in Sleep EEG Patterns in Self-Limited Childhood Epilepsies |
| title_sort | clinical and electrical evolution of pseudo spike wave activation in sleep eeg patterns in self limited childhood epilepsies |
| topic | pseudo-swas seleas selfe type 1 occipitofrontal spikes |
| url | https://journals.lww.com/10.4103/aian.aian_899_24 |
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