Controlled induction of type 2 diabetes in mice using high fat diet and osmotic-mini pump infused streptozotocin

Controlled induction of type 2 diabetes in mice using high fat diet and osmotic-mini pump infused streptozotocin

Abstract Type 2 diabetes (T2D) is a progressive metabolic disorder characterised by obesity, insulin resistance, impaired glucose tolerance, and hyperglycaemia. The long time-course of T2D in humans makes accurate modelling of sustained T2D in animal models difficult. The goal of this study was to d...

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Bibliographic Details
Main Authors: Emily H. Attrill, Oscar Scharapow, Sathya Perera, Sophie Mayne, Nicole Sumargo, Renee M. Ross, Stephen M. Richards, Brad A. Sutherland, Dino Premilovac
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
High fat diet
Streptozotocin
Type 2 diabetes
Obesity
Insulin resistance
Mouse model
Online Access:https://doi.org/10.1038/s41598-025-89162-2
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