Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma
Purpose. To evaluate the microvascular changes at the peripapillary area and optic disc in glaucomatous eyes after IOP lowering by trabeculectomy using OCT angiography. Methods. 25 patients with primary open-angle glaucoma (POAG) who underwent trabeculectomy by a single surgeon were evaluated. Using...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/8909714 |
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| author | Jung Hee In So Yeon Lee Seok Ho Cho Young Jae Hong |
| author_facet | Jung Hee In So Yeon Lee Seok Ho Cho Young Jae Hong |
| author_sort | Jung Hee In |
| collection | DOAJ |
| description | Purpose. To evaluate the microvascular changes at the peripapillary area and optic disc in glaucomatous eyes after IOP lowering by trabeculectomy using OCT angiography. Methods. 25 patients with primary open-angle glaucoma (POAG) who underwent trabeculectomy by a single surgeon were evaluated. Using optical coherence tomography angiography, vessel density was evaluated within the whole image, peripapillary, nasal region, and temporal region. Peripapillary vessel density was measured preoperative, 1 week, 1 month, and 3 months postoperatively in POAG patients. Reversal of vessel density was calculated for all analyzed areas. Results. The intraocular pressure (IOP) decreased from 30.92 ± 6.32 mmHg (range, 18–44) to 12.64 ± 3.35 mmHg (range, 8–22) at 3-month postoperatively. Compared with the preoperative baseline value, whole vessel density, peripapillary vessel density (PvD), and PvD in nasal region and temporal region were significantly increased at 3-month postoperatively. The magnitude of the vessel density reversal was significantly associated with higher preoperative IOP and greater IOP reduction. Conclusions. A significant increase in the peripapillary vessel density was demonstrated after trabeculectomy using OCT angiography. The reversal of peripapillary vessel density was associated with higher preoperative IOP and greater IOP reduction. Our postoperative results suggest that the ocular perfusion impairment by high intraocular pressure can be improved by IOP reduction, and the reversal of microvasculature may contribute to the rate of glaucoma progression. |
| format | Article |
| id | doaj-art-d3ba1f9665a14ef08954c5814d6265ad |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-d3ba1f9665a14ef08954c5814d6265ad2025-02-03T06:01:42ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/89097148909714Peripapillary Vessel Density Reversal after Trabeculectomy in GlaucomaJung Hee In0So Yeon Lee1Seok Ho Cho2Young Jae Hong3Glaucoma Center, Nune Eye Hospital, Seoul, Republic of KoreaGlaucoma Center, Nune Eye Hospital, Seoul, Republic of KoreaGlaucoma Center, Nune Eye Hospital, Seoul, Republic of KoreaGlaucoma Center, Nune Eye Hospital, Seoul, Republic of KoreaPurpose. To evaluate the microvascular changes at the peripapillary area and optic disc in glaucomatous eyes after IOP lowering by trabeculectomy using OCT angiography. Methods. 25 patients with primary open-angle glaucoma (POAG) who underwent trabeculectomy by a single surgeon were evaluated. Using optical coherence tomography angiography, vessel density was evaluated within the whole image, peripapillary, nasal region, and temporal region. Peripapillary vessel density was measured preoperative, 1 week, 1 month, and 3 months postoperatively in POAG patients. Reversal of vessel density was calculated for all analyzed areas. Results. The intraocular pressure (IOP) decreased from 30.92 ± 6.32 mmHg (range, 18–44) to 12.64 ± 3.35 mmHg (range, 8–22) at 3-month postoperatively. Compared with the preoperative baseline value, whole vessel density, peripapillary vessel density (PvD), and PvD in nasal region and temporal region were significantly increased at 3-month postoperatively. The magnitude of the vessel density reversal was significantly associated with higher preoperative IOP and greater IOP reduction. Conclusions. A significant increase in the peripapillary vessel density was demonstrated after trabeculectomy using OCT angiography. The reversal of peripapillary vessel density was associated with higher preoperative IOP and greater IOP reduction. Our postoperative results suggest that the ocular perfusion impairment by high intraocular pressure can be improved by IOP reduction, and the reversal of microvasculature may contribute to the rate of glaucoma progression.http://dx.doi.org/10.1155/2018/8909714 |
| spellingShingle | Jung Hee In So Yeon Lee Seok Ho Cho Young Jae Hong Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma Journal of Ophthalmology |
| title | Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma |
| title_full | Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma |
| title_fullStr | Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma |
| title_full_unstemmed | Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma |
| title_short | Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma |
| title_sort | peripapillary vessel density reversal after trabeculectomy in glaucoma |
| url | http://dx.doi.org/10.1155/2018/8909714 |
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