Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification
Abstract Purpose To valuate the role of nonmalignant nephrological findings and renal MRI radiomics in differentiating molecular subtypes of Beckwith–Wiedemann syndrome (BWS). Materials and methods Clinical data and abdominal MRI scans of 49 patients who underwent partial glossectomy between July 20...
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BMC
2025-06-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-025-03841-x |
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| author | Mei Bai Xiansheng Wu Jinghui Wang Miaoying Zhang Zhongwei Qiao Lin Zhang Jungang Liu |
| author_facet | Mei Bai Xiansheng Wu Jinghui Wang Miaoying Zhang Zhongwei Qiao Lin Zhang Jungang Liu |
| author_sort | Mei Bai |
| collection | DOAJ |
| description | Abstract Purpose To valuate the role of nonmalignant nephrological findings and renal MRI radiomics in differentiating molecular subtypes of Beckwith–Wiedemann syndrome (BWS). Materials and methods Clinical data and abdominal MRI scans of 49 patients who underwent partial glossectomy between July 2019 and March 2024 were retrospectively analysed. Patients were categorized into two subtypes: BWSUPD+IC1 (24 cases, with a predisposition to renal involvement) and BWSIC2 (25 cases, with a lower risk of renal involvement), based on genetic testing. Pearson correlation analysis was conducted to evaluate the relationship between patients’ age and renal volume. Radiomic features derived from the T2WI sequence and the ADC map were selected to construct single-sequence and combined models. Delong test was used to compare the performance of the models. Results Clinically, the BWSUPD+IC1 subtype exhibited a lower incidence of ear creases/pits (P = 0.048) and omphalocele/umbilical hernia (P = 0.032) compared to the BWSIC2 subtype. Abdominal MRI findings indicated the BWSUPD+IC1 subtype had larger total renal volume (P = 0.017) and a weaker correlation between total renal volume and patients’ age (r = 0.38). Notably, 91.84% (45/49) of BWS patients exhibited a total renal volume exceeding the normal population’s upper limit, with the IC1 subtype demonstrating the largest mean volume. The BWSUPD+IC1 subtype showed higher incidences of nonmalignant renal (P = 0.013) and non-renal abdominal abnormalities. The T2WI, ADC, and combined models achieved the highest area under the receiver operating characteristic (ROC) curves (AUCs) of 0.837, 0.882 and 0.954 (P > 0.05), respectively. Conclusion Nonmalignant renal abnormalities and MRI radiomics models have potential as alternative imaging tools for the identification of renal predisposition genotypes and the surveillance of renal size change in BWS patients. |
| format | Article |
| id | doaj-art-d3a5c89a670e4cd29709b1a4e46c55b6 |
| institution | OA Journals |
| issn | 1750-1172 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj-art-d3a5c89a670e4cd29709b1a4e46c55b62025-08-20T02:10:32ZengBMCOrphanet Journal of Rare Diseases1750-11722025-06-0120111410.1186/s13023-025-03841-xRenal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identificationMei Bai0Xiansheng Wu1Jinghui Wang2Miaoying Zhang3Zhongwei Qiao4Lin Zhang5Jungang Liu6Department of Radiology, Children’s Hospital of Fudan UniversityDepartment of Radiology, Xiamen Children’s Hospital (Children’s Hospital of Fudan University Xiamen Branch)Department of Clinical Laboratory, Xiamen Children’s Hospital (Children’s Hospital of Fudan University Xiamen Branch)Department of Endocrinology, Children’s Hospital of Fudan UniversityDepartment of Radiology, Children’s Hospital of Fudan UniversityDepartment of Radiology, Xiamen Children’s Hospital (Children’s Hospital of Fudan University Xiamen Branch)Department of Radiology, Xiamen Children’s Hospital (Children’s Hospital of Fudan University Xiamen Branch)Abstract Purpose To valuate the role of nonmalignant nephrological findings and renal MRI radiomics in differentiating molecular subtypes of Beckwith–Wiedemann syndrome (BWS). Materials and methods Clinical data and abdominal MRI scans of 49 patients who underwent partial glossectomy between July 2019 and March 2024 were retrospectively analysed. Patients were categorized into two subtypes: BWSUPD+IC1 (24 cases, with a predisposition to renal involvement) and BWSIC2 (25 cases, with a lower risk of renal involvement), based on genetic testing. Pearson correlation analysis was conducted to evaluate the relationship between patients’ age and renal volume. Radiomic features derived from the T2WI sequence and the ADC map were selected to construct single-sequence and combined models. Delong test was used to compare the performance of the models. Results Clinically, the BWSUPD+IC1 subtype exhibited a lower incidence of ear creases/pits (P = 0.048) and omphalocele/umbilical hernia (P = 0.032) compared to the BWSIC2 subtype. Abdominal MRI findings indicated the BWSUPD+IC1 subtype had larger total renal volume (P = 0.017) and a weaker correlation between total renal volume and patients’ age (r = 0.38). Notably, 91.84% (45/49) of BWS patients exhibited a total renal volume exceeding the normal population’s upper limit, with the IC1 subtype demonstrating the largest mean volume. The BWSUPD+IC1 subtype showed higher incidences of nonmalignant renal (P = 0.013) and non-renal abdominal abnormalities. The T2WI, ADC, and combined models achieved the highest area under the receiver operating characteristic (ROC) curves (AUCs) of 0.837, 0.882 and 0.954 (P > 0.05), respectively. Conclusion Nonmalignant renal abnormalities and MRI radiomics models have potential as alternative imaging tools for the identification of renal predisposition genotypes and the surveillance of renal size change in BWS patients.https://doi.org/10.1186/s13023-025-03841-xRadiomicsBeckwith–Wiedeman syndromeKidneyGenotype |
| spellingShingle | Mei Bai Xiansheng Wu Jinghui Wang Miaoying Zhang Zhongwei Qiao Lin Zhang Jungang Liu Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification Orphanet Journal of Rare Diseases Radiomics Beckwith–Wiedeman syndrome Kidney Genotype |
| title | Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification |
| title_full | Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification |
| title_fullStr | Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification |
| title_full_unstemmed | Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification |
| title_short | Renal MRI radiomics in Beckwith–Wiedemann syndrome: a novel imaging approach for genotype identification |
| title_sort | renal mri radiomics in beckwith wiedemann syndrome a novel imaging approach for genotype identification |
| topic | Radiomics Beckwith–Wiedeman syndrome Kidney Genotype |
| url | https://doi.org/10.1186/s13023-025-03841-x |
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