Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy
The g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> intercalation composite material was successfully synthesized and used as the adsorbent in the hemoperfusion device. Then, the cytotoxicity and hemolysis rate were studied. The experimental results proved that g-C&l...
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2025-06-01
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| Series: | Molecules |
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| author | Lingdong Meng Shouxuan Tao Liyao Wang Yu Cao Jianhua Hou Chengyin Wang |
| author_facet | Lingdong Meng Shouxuan Tao Liyao Wang Yu Cao Jianhua Hou Chengyin Wang |
| author_sort | Lingdong Meng |
| collection | DOAJ |
| description | The g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> intercalation composite material was successfully synthesized and used as the adsorbent in the hemoperfusion device. Then, the cytotoxicity and hemolysis rate were studied. The experimental results proved that g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> was non-toxic to cells and would not cause hemolysis. The adsorption and removal performance of the composite material for bilirubin (BR) was explored as well. The maximum adsorption capacity for BR was 850 mg·g<sup>−1</sup>. Compared with the chemical hemoperfusion adsorbent coconut shell activated carbon (AC), the g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> material presented excellent adsorption performance. Furthermore, SEM, infrared spectroscopy, XPS and other characterizations results indicated that g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> has an effective adsorption effect on bilirubin, and the main adsorption mechanism is chemical adsorption. This study demonstrates that g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> may be a potential adsorbent for hemoperfusion in the treatment of hyperbilirubinemia. |
| format | Article |
| id | doaj-art-d3a21be739b04c07afbec14062c43e13 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-d3a21be739b04c07afbec14062c43e132025-08-20T03:28:29ZengMDPI AGMolecules1420-30492025-06-013013272910.3390/molecules30132729Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion TherapyLingdong Meng0Shouxuan Tao1Liyao Wang2Yu Cao3Jianhua Hou4Chengyin Wang5Hemodialysis Center of Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou 225000, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225000, ChinaFaculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, ChinaCollege of Environmental Science and Engineering, Yangzhou University, Yangzhou 225000, ChinaCollege of Environmental Science and Engineering, Yangzhou University, Yangzhou 225000, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225000, ChinaThe g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> intercalation composite material was successfully synthesized and used as the adsorbent in the hemoperfusion device. Then, the cytotoxicity and hemolysis rate were studied. The experimental results proved that g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> was non-toxic to cells and would not cause hemolysis. The adsorption and removal performance of the composite material for bilirubin (BR) was explored as well. The maximum adsorption capacity for BR was 850 mg·g<sup>−1</sup>. Compared with the chemical hemoperfusion adsorbent coconut shell activated carbon (AC), the g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> material presented excellent adsorption performance. Furthermore, SEM, infrared spectroscopy, XPS and other characterizations results indicated that g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> has an effective adsorption effect on bilirubin, and the main adsorption mechanism is chemical adsorption. This study demonstrates that g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> may be a potential adsorbent for hemoperfusion in the treatment of hyperbilirubinemia.https://www.mdpi.com/1420-3049/30/13/2729g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub>bilirubin (BR)hemoperfusionadsorbent |
| spellingShingle | Lingdong Meng Shouxuan Tao Liyao Wang Yu Cao Jianhua Hou Chengyin Wang Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy Molecules g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> bilirubin (BR) hemoperfusion adsorbent |
| title | Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy |
| title_full | Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy |
| title_fullStr | Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy |
| title_full_unstemmed | Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy |
| title_short | Heterojunction-Engineered g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy |
| title_sort | heterojunction engineered g c sub 3 sub n sub 4 sub tio sub 2 sub nanocomposites with superior bilirubin removal efficiency for enhanced hemoperfusion therapy |
| topic | g-C<sub>3</sub>N<sub>4</sub>/TiO<sub>2</sub> bilirubin (BR) hemoperfusion adsorbent |
| url | https://www.mdpi.com/1420-3049/30/13/2729 |
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