NETs and oncologic process
Neutrophil Extracellular Traps (NETs) represent the networks consisting of DNA, histones, and proteins produced by activated neutrophils. Such structures have been proved to play a crucial role in inducing neutrophil innate immune response in the pathogenesis of such autoimmune conditions as systemi...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IRBIS LLC
2021-03-01
|
| Series: | Акушерство, гинекология и репродукция |
| Subjects: | |
| Online Access: | https://www.gynecology.su/jour/article/view/930 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849697320163082240 |
|---|---|
| author | E. V. Slukhanchuk |
| author_facet | E. V. Slukhanchuk |
| author_sort | E. V. Slukhanchuk |
| collection | DOAJ |
| description | Neutrophil Extracellular Traps (NETs) represent the networks consisting of DNA, histones, and proteins produced by activated neutrophils. Such structures have been proved to play a crucial role in inducing neutrophil innate immune response in the pathogenesis of such autoimmune conditions as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, as well as in the pathogenesis of other non-infectious processes, e. g., clotting disorders, thrombosis, diabetes, atherosclerosis, vasculitis and oncology diseases. Recent studies on animal models and human pathologies have uncovered a tremendous role for NETs in tumor progression and metastasis. In this regard, NETs should be considered as pro-oncogenic substances, which further investigation will provide an opportunity to develop new therapeutic strategies. |
| format | Article |
| id | doaj-art-d3a059928be94d0d9e359d8f931550eb |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2021-03-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-d3a059928be94d0d9e359d8f931550eb2025-08-20T03:19:14ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942021-03-0115110711610.17749/2313-7347/ob.gyn.rep.2021.204626NETs and oncologic processE. V. Slukhanchuk0Petrovsky National Research Centre of SurgeryNeutrophil Extracellular Traps (NETs) represent the networks consisting of DNA, histones, and proteins produced by activated neutrophils. Such structures have been proved to play a crucial role in inducing neutrophil innate immune response in the pathogenesis of such autoimmune conditions as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, as well as in the pathogenesis of other non-infectious processes, e. g., clotting disorders, thrombosis, diabetes, atherosclerosis, vasculitis and oncology diseases. Recent studies on animal models and human pathologies have uncovered a tremendous role for NETs in tumor progression and metastasis. In this regard, NETs should be considered as pro-oncogenic substances, which further investigation will provide an opportunity to develop new therapeutic strategies.https://www.gynecology.su/jour/article/view/930neutrophil extracellular trapsnetsnetosistumor-associated neutrophilstumor microenvironment |
| spellingShingle | E. V. Slukhanchuk NETs and oncologic process Акушерство, гинекология и репродукция neutrophil extracellular traps nets netosis tumor-associated neutrophils tumor microenvironment |
| title | NETs and oncologic process |
| title_full | NETs and oncologic process |
| title_fullStr | NETs and oncologic process |
| title_full_unstemmed | NETs and oncologic process |
| title_short | NETs and oncologic process |
| title_sort | nets and oncologic process |
| topic | neutrophil extracellular traps nets netosis tumor-associated neutrophils tumor microenvironment |
| url | https://www.gynecology.su/jour/article/view/930 |
| work_keys_str_mv | AT evslukhanchuk netsandoncologicprocess |