Amiodarone-related keratopathy and optic neuropathy: case report and literature review
Amiodarone, a highly effective yet lipophilic antiarrhythmic drug with prolonged half-life, is associated with systemic and ocular complications. While keratopathy being the most prevalent, affecting 70–100% of long-term users, amiodarone-associated optic neuropathy (AAON), though rare (incidence: 0...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1572461/full |
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| author | Nana Meng Nana Meng Nana Meng Leizhou Xia Yiqing Gong Yiqing Gong Peirong Lu |
| author_facet | Nana Meng Nana Meng Nana Meng Leizhou Xia Yiqing Gong Yiqing Gong Peirong Lu |
| author_sort | Nana Meng |
| collection | DOAJ |
| description | Amiodarone, a highly effective yet lipophilic antiarrhythmic drug with prolonged half-life, is associated with systemic and ocular complications. While keratopathy being the most prevalent, affecting 70–100% of long-term users, amiodarone-associated optic neuropathy (AAON), though rare (incidence: 0.36–2%), can induce diverse visual impairments, ranging from mild deficits to profound vision loss. Given that patients on amiodarone frequently possess the risk factors of vascular diseases, it is essential to differentiate the diagnosis of AAON from non-arteritic anterior ischemic optic neuropathy (AION). This study reports a 61-year-old man who developed both corneal deposition and optic neuropathy during systemic amiodarone therapy. We further analyze the clinical features of keratopathy and optic neuropathy caused by amiodarone through a comprehensive literature review, aiming to enhance diagnostic recognition and management strategies. |
| format | Article |
| id | doaj-art-d39f99f671ca44c586c90feb6cfbcbfe |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-d39f99f671ca44c586c90feb6cfbcbfe2025-08-20T01:55:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15724611572461Amiodarone-related keratopathy and optic neuropathy: case report and literature reviewNana Meng0Nana Meng1Nana Meng2Leizhou Xia3Yiqing Gong4Yiqing Gong5Peirong Lu6Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Ophthalmology, Affiliated People's Hospital, Jiangsu University, Zhenjiang, ChinaZhenjiang Kangfu Eye Hospital, Zhenjiang, ChinaDepartment of General Surgery, Affiliated People's Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Ophthalmology, Affiliated People's Hospital, Jiangsu University, Zhenjiang, ChinaZhenjiang Kangfu Eye Hospital, Zhenjiang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaAmiodarone, a highly effective yet lipophilic antiarrhythmic drug with prolonged half-life, is associated with systemic and ocular complications. While keratopathy being the most prevalent, affecting 70–100% of long-term users, amiodarone-associated optic neuropathy (AAON), though rare (incidence: 0.36–2%), can induce diverse visual impairments, ranging from mild deficits to profound vision loss. Given that patients on amiodarone frequently possess the risk factors of vascular diseases, it is essential to differentiate the diagnosis of AAON from non-arteritic anterior ischemic optic neuropathy (AION). This study reports a 61-year-old man who developed both corneal deposition and optic neuropathy during systemic amiodarone therapy. We further analyze the clinical features of keratopathy and optic neuropathy caused by amiodarone through a comprehensive literature review, aiming to enhance diagnostic recognition and management strategies.https://www.frontiersin.org/articles/10.3389/fmed.2025.1572461/fullamiodaroneoptic neuropathykeratopathyamiodarone-associated optic neuropathyanterior ischemic optic neuropathy |
| spellingShingle | Nana Meng Nana Meng Nana Meng Leizhou Xia Yiqing Gong Yiqing Gong Peirong Lu Amiodarone-related keratopathy and optic neuropathy: case report and literature review Frontiers in Medicine amiodarone optic neuropathy keratopathy amiodarone-associated optic neuropathy anterior ischemic optic neuropathy |
| title | Amiodarone-related keratopathy and optic neuropathy: case report and literature review |
| title_full | Amiodarone-related keratopathy and optic neuropathy: case report and literature review |
| title_fullStr | Amiodarone-related keratopathy and optic neuropathy: case report and literature review |
| title_full_unstemmed | Amiodarone-related keratopathy and optic neuropathy: case report and literature review |
| title_short | Amiodarone-related keratopathy and optic neuropathy: case report and literature review |
| title_sort | amiodarone related keratopathy and optic neuropathy case report and literature review |
| topic | amiodarone optic neuropathy keratopathy amiodarone-associated optic neuropathy anterior ischemic optic neuropathy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1572461/full |
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