Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease.

Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease.

Antibody therapies for Alzheimer's Disease (AD) hold promise but have been limited by the inability of these proteins to migrate efficiently across the blood brain barrier (BBB). Central nervous system (CNS) gene transfer by vectors like adeno-associated virus (AAV) overcome this barrier by all...

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Main Authors: Bradford M Elmer, Kurt A Swanson, Dinesh S Bangari, Peter A Piepenhagen, Errin Roberts, Tatyana Taksir, Lei Guo, Maria-Carmen Obinu, Pascal Barneoud, Susan Ryan, Bailin Zhang, Laurent Pradier, Zhi-Yong Yang, Gary J Nabel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226245&type=printable
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