High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.

An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage....

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Main Authors: Nuha R Mansour, Ross Paveley, J Mark F Gardner, Andrew S Bell, Tanya Parkinson, Quentin Bickle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004659&type=printable
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author Nuha R Mansour
Ross Paveley
J Mark F Gardner
Andrew S Bell
Tanya Parkinson
Quentin Bickle
author_facet Nuha R Mansour
Ross Paveley
J Mark F Gardner
Andrew S Bell
Tanya Parkinson
Quentin Bickle
author_sort Nuha R Mansour
collection DOAJ
description An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. A total of almost 300,000 compounds were screened using a high throughput assay based on motility of worm larvae and image analysis of assay plates. Hits were screened against juvenile and adult worms to identify broadly active compounds and against a mammalian cell line to assess cytotoxicity. A number of compounds were identified as promising leads for further chemical optimization.
format Article
id doaj-art-d3931aef593f48d39c5e473c5df191f8
institution Kabale University
issn 1935-2727
1935-2735
language English
publishDate 2016-04-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS Neglected Tropical Diseases
spelling doaj-art-d3931aef593f48d39c5e473c5df191f82025-08-20T03:24:30ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352016-04-01104e000465910.1371/journal.pntd.0004659High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.Nuha R MansourRoss PaveleyJ Mark F GardnerAndrew S BellTanya ParkinsonQuentin BickleAn estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. A total of almost 300,000 compounds were screened using a high throughput assay based on motility of worm larvae and image analysis of assay plates. Hits were screened against juvenile and adult worms to identify broadly active compounds and against a mammalian cell line to assess cytotoxicity. A number of compounds were identified as promising leads for further chemical optimization.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004659&type=printable
spellingShingle Nuha R Mansour
Ross Paveley
J Mark F Gardner
Andrew S Bell
Tanya Parkinson
Quentin Bickle
High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
PLoS Neglected Tropical Diseases
title High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
title_full High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
title_fullStr High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
title_full_unstemmed High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
title_short High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
title_sort high throughput screening identifies novel lead compounds with activity against larval juvenile and adult schistosoma mansoni
url https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004659&type=printable
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