Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants
ObjectiveWe evaluated the effect of transcatheter PDA closure (TCDC) on pulmonary edema by chest x-ray and respiratory status in preterm infants and identified factors contributing to clinical improvement.Study designA retrospective review of TCDC in 68 premature infants from January 2017 to June 20...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1472431/full |
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| author | Ahmad Chmaisse Kaitlin E. Swanson Michael M. Ross Matthew L. Cooper Diane E. Lorant Ryan D. Alexy |
| author_facet | Ahmad Chmaisse Kaitlin E. Swanson Michael M. Ross Matthew L. Cooper Diane E. Lorant Ryan D. Alexy |
| author_sort | Ahmad Chmaisse |
| collection | DOAJ |
| description | ObjectiveWe evaluated the effect of transcatheter PDA closure (TCDC) on pulmonary edema by chest x-ray and respiratory status in preterm infants and identified factors contributing to clinical improvement.Study designA retrospective review of TCDC in 68 premature infants from January 2017 to June 2021. Chest x-rays were reviewed to assess pulmonary edema. Multiple clinical characteristics were also evaluated.Results40% of patients weaned respiratory support. x-ray haziness change was not significantly different between groups (p = 0.086), however trended toward significance. 59% had decreased haziness and 16% had a marked decrease. Smaller, younger infants were more likely to wean support and have improved edema.ConclusionChest x-ray haziness improved after TCDC, with smaller infants and earlier closure having more improvement. Infants with lung disease had less noticeable improved edema, indicating the difficulty to assess the hemodynamic significance of their PDA prior to closure. Further studies are needed to identify which neonates benefit most from TCDC. |
| format | Article |
| id | doaj-art-d38dd1b59c0b440cb51e2d272fb99c5c |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-d38dd1b59c0b440cb51e2d272fb99c5c2025-08-20T02:24:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-04-011310.3389/fped.2025.14724311472431Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infantsAhmad Chmaisse0Kaitlin E. Swanson1Michael M. Ross2Matthew L. Cooper3Diane E. Lorant4Ryan D. Alexy5Division of Cardiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, United StatesDivision of Cardiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, United StatesDivision of Cardiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Radiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, United StatesDivision of Neonatology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, United StatesDivision of Cardiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, United StatesObjectiveWe evaluated the effect of transcatheter PDA closure (TCDC) on pulmonary edema by chest x-ray and respiratory status in preterm infants and identified factors contributing to clinical improvement.Study designA retrospective review of TCDC in 68 premature infants from January 2017 to June 2021. Chest x-rays were reviewed to assess pulmonary edema. Multiple clinical characteristics were also evaluated.Results40% of patients weaned respiratory support. x-ray haziness change was not significantly different between groups (p = 0.086), however trended toward significance. 59% had decreased haziness and 16% had a marked decrease. Smaller, younger infants were more likely to wean support and have improved edema.ConclusionChest x-ray haziness improved after TCDC, with smaller infants and earlier closure having more improvement. Infants with lung disease had less noticeable improved edema, indicating the difficulty to assess the hemodynamic significance of their PDA prior to closure. Further studies are needed to identify which neonates benefit most from TCDC.https://www.frontiersin.org/articles/10.3389/fped.2025.1472431/fullinterventional pediatric cardiologytranscatheter PDA closurepreterm infantsrespiratory statuspatent ductus arteriosus |
| spellingShingle | Ahmad Chmaisse Kaitlin E. Swanson Michael M. Ross Matthew L. Cooper Diane E. Lorant Ryan D. Alexy Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants Frontiers in Pediatrics interventional pediatric cardiology transcatheter PDA closure preterm infants respiratory status patent ductus arteriosus |
| title | Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants |
| title_full | Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants |
| title_fullStr | Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants |
| title_full_unstemmed | Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants |
| title_short | Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants |
| title_sort | improvement of pulmonary edema and respiratory status after transcatheter pda closure in the smallest and most premature infants |
| topic | interventional pediatric cardiology transcatheter PDA closure preterm infants respiratory status patent ductus arteriosus |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1472431/full |
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