Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Abstract A broad chemical genetic screen in Mycobacterium tuberculosis (Mtb) identified compounds (BRD-8000.3 and BRD-9327) that inhibit the essential efflux pump EfpA. To understand the mechanisms of inhibition, we determined the structures of EfpA with these inhibitors bound at 2.7-3.4 Å resolutio...

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Main Authors: Nitesh Kumar Khandelwal, Meghna Gupta, James E. Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y. Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T. Hung, Robert M. Stroud
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58133-6
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