Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation
Objective: To explore the effect of astaxanthin on immune function and myocardial injury in mice with chronic sleep deprivation (CSD). Methods: A modified multi-platform water environment method was used to establish an CSD mouse model for two weeks. At the same time, mice were intragastrically admi...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Food Publishing Company
2024-12-01
|
| Series: | Shipin Kexue |
| Subjects: | |
| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-23-017.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832539853602947072 |
|---|---|
| author | FENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui |
| author_facet | FENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui |
| author_sort | FENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui |
| collection | DOAJ |
| description | Objective: To explore the effect of astaxanthin on immune function and myocardial injury in mice with chronic sleep deprivation (CSD). Methods: A modified multi-platform water environment method was used to establish an CSD mouse model for two weeks. At the same time, mice were intragastrically administered with astaxanthin at different doses. Immune function and myocardial injury were evaluated by measuring organ coefficients as well as using the carbon clearance test and commercial enzyme-linked immunosorbent assay (ELISA) kits. The targets of astaxanthin and related biological processes and pathways were analyzed by network pharmacology. Results: Compared with the model group, body mass, phagocytic index and clearance index significantly increased in the treatment groups, and heart, spleen and pancreas coefficients decreased. Moreover, the levels of serum creatine kinase (CK), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), glutathione peroxidase (GSH-Px), interleukin (IL)-1β, IL-6, nitric oxide synthase (NOS) and γ-glutamyl transpeptidase (γ-GT) rose markedly in each treatment group, and the level of malondialdehyde (MDA) significantly declined. Conclusion: Astaxanthin greatly ameliorates immune dysfunction and myocardial injury caused by CSD, perhaps by regulating the neurotrophic factors, Toll-like receptor, nuclear factor-κB (NF-κB), T cell receptor and apoptosis signaling pathways and inhibiting inflammatory response. |
| format | Article |
| id | doaj-art-d38253ae8bf144c2bcb71bbf88c28cab |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-d38253ae8bf144c2bcb71bbf88c28cab2025-02-05T09:07:53ZengChina Food Publishing CompanyShipin Kexue1002-66302024-12-01452315015810.7506/spkx1002-6630-20240428-255Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep DeprivationFENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui0(1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; 2. Xiamen Key Laboratory of Natural Medicine Research and Development, Xiamen Health and Medical Big Data Center (Xiamen Medicine Research Institute), Xiamen 361008, China)Objective: To explore the effect of astaxanthin on immune function and myocardial injury in mice with chronic sleep deprivation (CSD). Methods: A modified multi-platform water environment method was used to establish an CSD mouse model for two weeks. At the same time, mice were intragastrically administered with astaxanthin at different doses. Immune function and myocardial injury were evaluated by measuring organ coefficients as well as using the carbon clearance test and commercial enzyme-linked immunosorbent assay (ELISA) kits. The targets of astaxanthin and related biological processes and pathways were analyzed by network pharmacology. Results: Compared with the model group, body mass, phagocytic index and clearance index significantly increased in the treatment groups, and heart, spleen and pancreas coefficients decreased. Moreover, the levels of serum creatine kinase (CK), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), glutathione peroxidase (GSH-Px), interleukin (IL)-1β, IL-6, nitric oxide synthase (NOS) and γ-glutamyl transpeptidase (γ-GT) rose markedly in each treatment group, and the level of malondialdehyde (MDA) significantly declined. Conclusion: Astaxanthin greatly ameliorates immune dysfunction and myocardial injury caused by CSD, perhaps by regulating the neurotrophic factors, Toll-like receptor, nuclear factor-κB (NF-κB), T cell receptor and apoptosis signaling pathways and inhibiting inflammatory response.https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-23-017.pdfastaxanthin; chronic sleep deprivation; immune function; myocardial injury; network pharmacology |
| spellingShingle | FENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation Shipin Kexue astaxanthin; chronic sleep deprivation; immune function; myocardial injury; network pharmacology |
| title | Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation |
| title_full | Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation |
| title_fullStr | Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation |
| title_full_unstemmed | Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation |
| title_short | Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation |
| title_sort | effect of astaxanthin on immune function and myocardial injury in mice with chronic sleep deprivation |
| topic | astaxanthin; chronic sleep deprivation; immune function; myocardial injury; network pharmacology |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-23-017.pdf |
| work_keys_str_mv | AT fengbiyunlilingyanlimingzhangjiayuanqihuanyangchenpingpingxuguanghui effectofastaxanthinonimmunefunctionandmyocardialinjuryinmicewithchronicsleepdeprivation |