Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia
Aggressive natural killer cell leukemia (ANKL) is a rare and often lethal lymphoproliferative disorder. Patients may present with constitutional symptoms, jaundice, skin infiltration, lymphadenopathy, and hepatosplenomegaly. ANKL can progress quickly to multiorgan failure and survival is usually mea...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/715615 |
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| _version_ | 1832562702218690560 |
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| author | Justin LaPorte Lawrence Morris John Koepke |
| author_facet | Justin LaPorte Lawrence Morris John Koepke |
| author_sort | Justin LaPorte |
| collection | DOAJ |
| description | Aggressive natural killer cell leukemia (ANKL) is a rare and often lethal lymphoproliferative disorder. Patients may present with constitutional symptoms, jaundice, skin infiltration, lymphadenopathy, and hepatosplenomegaly. ANKL can progress quickly to multiorgan failure and survival is usually measured in weeks. Although a rapid and accurate diagnosis is critical, unfortunately there is no hallmark diagnostic marker of ANKL. We report a case of a 48-year-old male who was able to obtain a complete remission following cisplatin-based chemotherapy. We describe the details of the chemotherapy regimens used and a literature review of the treatment of ANKL. |
| format | Article |
| id | doaj-art-d380c17cf023413e9c08f26e54ce7f3c |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d380c17cf023413e9c08f26e54ce7f3c2025-02-03T01:22:03ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/715615715615Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell LeukemiaJustin LaPorte0Lawrence Morris1John Koepke2The Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA 30342, USAThe Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA 30342, USANorthside Hospital Pathology Department, Atlanta, GA 30342, USAAggressive natural killer cell leukemia (ANKL) is a rare and often lethal lymphoproliferative disorder. Patients may present with constitutional symptoms, jaundice, skin infiltration, lymphadenopathy, and hepatosplenomegaly. ANKL can progress quickly to multiorgan failure and survival is usually measured in weeks. Although a rapid and accurate diagnosis is critical, unfortunately there is no hallmark diagnostic marker of ANKL. We report a case of a 48-year-old male who was able to obtain a complete remission following cisplatin-based chemotherapy. We describe the details of the chemotherapy regimens used and a literature review of the treatment of ANKL.http://dx.doi.org/10.1155/2015/715615 |
| spellingShingle | Justin LaPorte Lawrence Morris John Koepke Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia Case Reports in Hematology |
| title | Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia |
| title_full | Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia |
| title_fullStr | Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia |
| title_full_unstemmed | Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia |
| title_short | Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia |
| title_sort | long complete remission achieved with the combination therapy of cisplatin and gemcitabine in a patient with aggressive natural killer cell leukemia |
| url | http://dx.doi.org/10.1155/2015/715615 |
| work_keys_str_mv | AT justinlaporte longcompleteremissionachievedwiththecombinationtherapyofcisplatinandgemcitabineinapatientwithaggressivenaturalkillercellleukemia AT lawrencemorris longcompleteremissionachievedwiththecombinationtherapyofcisplatinandgemcitabineinapatientwithaggressivenaturalkillercellleukemia AT johnkoepke longcompleteremissionachievedwiththecombinationtherapyofcisplatinandgemcitabineinapatientwithaggressivenaturalkillercellleukemia |