High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes
Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation. Mitochondrial ribosomal protein S23 overexpression has...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-07-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317709127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849700755700711424 |
|---|---|
| author | Meng Pu Jianlin Wang Qike Huang Ge Zhao Congcong Xia Runze Shang Zhuochao Zhang Zhenyuan Bian Xishegn Yang Kaishan Tao |
| author_facet | Meng Pu Jianlin Wang Qike Huang Ge Zhao Congcong Xia Runze Shang Zhuochao Zhang Zhenyuan Bian Xishegn Yang Kaishan Tao |
| author_sort | Meng Pu |
| collection | DOAJ |
| description | Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation. Mitochondrial ribosomal protein S23 overexpression has been found in many types of cancer. In this study, we explored mitochondrial ribosomal protein S23 expression in primary hepatocellular carcinoma tissues compared with matched adjacent non-tumoral liver tissues using mitochondrial ribosomal protein S23 messenger RNA and protein levels collected from public databases and clinical samples. Immunohistochemistry was performed to analyze the relationship between mitochondrial ribosomal protein S23 and various clinicopathological features. The results indicated that mitochondrial ribosomal protein S23 was significantly overexpressed in hepatocellular carcinoma. High mitochondrial ribosomal protein S23 expression was correlated with the tumor size and tumor–metastasis–node stage. Moreover, patients with high mitochondrial ribosomal protein S23 expression levels presented poorer survival rates. Mitochondrial ribosomal protein S23 was an independent prognostic factor for survival, especially at the early stage of hepatocellular carcinoma. In addition, the downregulation of mitochondrial ribosomal protein S23 decreased the proliferation of hepatocellular carcinoma in vitro and in vivo. In conclusion, we verified for the first time that mitochondrial ribosomal protein S23 expression was upregulated in hepatocellular carcinoma. High mitochondrial ribosomal protein S23 levels can predict poor clinical outcomes in hepatocellular carcinoma, and this protein plays a key role in tumor proliferation. Therefore, mitochondrial ribosomal protein S23 may be a potential therapeutic target for hepatocellular carcinoma. |
| format | Article |
| id | doaj-art-d37d6b9c9cc54d419d356e958da22c5a |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-d37d6b9c9cc54d419d356e958da22c5a2025-08-20T03:18:09ZengSAGE PublishingTumor Biology1423-03802017-07-013910.1177/1010428317709127High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomesMeng Pu0Jianlin Wang1Qike Huang2Ge Zhao3Congcong Xia4Runze Shang5Zhuochao Zhang6Zhenyuan Bian7Xishegn Yang8Kaishan Tao9Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaHepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation. Mitochondrial ribosomal protein S23 overexpression has been found in many types of cancer. In this study, we explored mitochondrial ribosomal protein S23 expression in primary hepatocellular carcinoma tissues compared with matched adjacent non-tumoral liver tissues using mitochondrial ribosomal protein S23 messenger RNA and protein levels collected from public databases and clinical samples. Immunohistochemistry was performed to analyze the relationship between mitochondrial ribosomal protein S23 and various clinicopathological features. The results indicated that mitochondrial ribosomal protein S23 was significantly overexpressed in hepatocellular carcinoma. High mitochondrial ribosomal protein S23 expression was correlated with the tumor size and tumor–metastasis–node stage. Moreover, patients with high mitochondrial ribosomal protein S23 expression levels presented poorer survival rates. Mitochondrial ribosomal protein S23 was an independent prognostic factor for survival, especially at the early stage of hepatocellular carcinoma. In addition, the downregulation of mitochondrial ribosomal protein S23 decreased the proliferation of hepatocellular carcinoma in vitro and in vivo. In conclusion, we verified for the first time that mitochondrial ribosomal protein S23 expression was upregulated in hepatocellular carcinoma. High mitochondrial ribosomal protein S23 levels can predict poor clinical outcomes in hepatocellular carcinoma, and this protein plays a key role in tumor proliferation. Therefore, mitochondrial ribosomal protein S23 may be a potential therapeutic target for hepatocellular carcinoma.https://doi.org/10.1177/1010428317709127 |
| spellingShingle | Meng Pu Jianlin Wang Qike Huang Ge Zhao Congcong Xia Runze Shang Zhuochao Zhang Zhenyuan Bian Xishegn Yang Kaishan Tao High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes Tumor Biology |
| title | High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes |
| title_full | High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes |
| title_fullStr | High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes |
| title_full_unstemmed | High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes |
| title_short | High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes |
| title_sort | high mrps23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes |
| url | https://doi.org/10.1177/1010428317709127 |
| work_keys_str_mv | AT mengpu highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT jianlinwang highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT qikehuang highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT gezhao highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT congcongxia highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT runzeshang highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT zhuochaozhang highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT zhenyuanbian highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT xishegnyang highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes AT kaishantao highmrps23expressioncontributestohepatocellularcarcinomaproliferationandindicatespoorsurvivaloutcomes |