Gi‐DREADD activation decreases Epithelial Na+ channel activity in renal principal cells

Gi‐DREADD activation decreases Epithelial Na+ channel activity in renal principal cells

Abstract The activity of the Epithelial Na+ Channel (ENaC) in renal principal cells (PC) fine‐tunes sodium excretion and consequently affects blood pressure. G‐coupled receptors play an important role in regulating ENaC activity. We previously explored the role of Gq and Gs in regulating ENaC activi...

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Bibliographic Details
Main Authors: Tarek Mohamed Abd El‐Aziz, Elena Mironova, James D. Stockand, Lucia A. Seale, Antonio G. Soares
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Physiological Reports
Subjects:
epithelial sodium channel
Gi‐DREADD
sodium excretion
Online Access:https://doi.org/10.14814/phy2.70433
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