The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES
ObjectiveThis study investigates the correlation between Life’s Essential 8 (LE8), a cardiovascular health (CVH) metric, and frailty in middle-aged and elderly individuals in the United States, also examining how depression mediates this relationship.MethodsParticipants from the NHANES 2005-2018 wer...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1578743/full |
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| author | Qiaoli Ma Zhijuan Zou Yanpeng Liu Lei Zhang |
| author_facet | Qiaoli Ma Zhijuan Zou Yanpeng Liu Lei Zhang |
| author_sort | Qiaoli Ma |
| collection | DOAJ |
| description | ObjectiveThis study investigates the correlation between Life’s Essential 8 (LE8), a cardiovascular health (CVH) metric, and frailty in middle-aged and elderly individuals in the United States, also examining how depression mediates this relationship.MethodsParticipants from the NHANES 2005-2018 were analyzed for correlations between LE8 and frailty, along with the combined effects of LE8 and depression using multiple logistic regression. Dose-response relationships were assessed using restricted cubic splines (RCS), and mediation analysis explored depression’s role. Sensitivity and subgroup analyses were conducted for result stability.ResultsThe study included 8,982 participants, with 3,103 frailty events. A higher LE8 score was significantly associated with a reduced risk of frailty, with adjusted odds ratios for the medium and high CVH groups at 0.49 (95% CI: 0.40-0.58, p < 0.001) and 0.21 (95% CI: 0.13-0.33, p < 0.001), respectively. The RCS model showed a negative dose-response relationship. No significant association was found between LE8 and frailty in the depressed population, where depression mediated 32.13% of the relationship.ConclusionMaintaining good cardiovascular health, as measured by LE8, is key to reducing frailty risk in middle-aged and elderly individuals. This underscores the importance of cardiovascular health assessments and targeted health programs to improve quality of life. |
| format | Article |
| id | doaj-art-d378eba137ff4e29a63ead2987177e6a |
| institution | DOAJ |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-d378eba137ff4e29a63ead2987177e6a2025-08-20T03:08:32ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-04-011610.3389/fpsyt.2025.15787431578743The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANESQiaoli Ma0Zhijuan Zou1Yanpeng Liu2Lei Zhang3Department of Cardiology, Zibo Central Hospital, Zibo, Shandong, ChinaDepartment of Orthopedic Trauma, Zibo Central Hospital, Zibo, Shandong, ChinaEmergency Department, Zibo Central Hospital, Zibo, Shandong, ChinaDepartment of Cardiology, Zibo Central Hospital, Zibo, Shandong, ChinaObjectiveThis study investigates the correlation between Life’s Essential 8 (LE8), a cardiovascular health (CVH) metric, and frailty in middle-aged and elderly individuals in the United States, also examining how depression mediates this relationship.MethodsParticipants from the NHANES 2005-2018 were analyzed for correlations between LE8 and frailty, along with the combined effects of LE8 and depression using multiple logistic regression. Dose-response relationships were assessed using restricted cubic splines (RCS), and mediation analysis explored depression’s role. Sensitivity and subgroup analyses were conducted for result stability.ResultsThe study included 8,982 participants, with 3,103 frailty events. A higher LE8 score was significantly associated with a reduced risk of frailty, with adjusted odds ratios for the medium and high CVH groups at 0.49 (95% CI: 0.40-0.58, p < 0.001) and 0.21 (95% CI: 0.13-0.33, p < 0.001), respectively. The RCS model showed a negative dose-response relationship. No significant association was found between LE8 and frailty in the depressed population, where depression mediated 32.13% of the relationship.ConclusionMaintaining good cardiovascular health, as measured by LE8, is key to reducing frailty risk in middle-aged and elderly individuals. This underscores the importance of cardiovascular health assessments and targeted health programs to improve quality of life.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1578743/fullLife’s Essential 8frailtydepressionNHANESCVH |
| spellingShingle | Qiaoli Ma Zhijuan Zou Yanpeng Liu Lei Zhang The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES Frontiers in Psychiatry Life’s Essential 8 frailty depression NHANES CVH |
| title | The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES |
| title_full | The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES |
| title_fullStr | The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES |
| title_full_unstemmed | The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES |
| title_short | The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES |
| title_sort | mediating and joint effects of depression in the association between cardiovascular health and frailty in middle aged and elderly people evidence from nhanes |
| topic | Life’s Essential 8 frailty depression NHANES CVH |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1578743/full |
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