Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024

Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024

IntroductionIrinotecan is a widely used chemotherapeutic agent for treating colorectal, pancreatic, and ovarian cancers. Despite its therapeutic efficacy, the safety profile of irinotecan necessitates continuous pharmacovigilance due to its association with severe adverse drug events (ADEs). Given i...

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Bibliographic Details
Main Authors: Siyu Lou, Huayou Chen, Zhiwei Cui, Xiyuan Zhang, Chengyu Zhu, Linmei Zhou, Yingyong Ou, Fan Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
irinotecan
real-world pharmacovigilance analysis
FAERS
JADER
adverse drug event
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1516449/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1516449/full

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